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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Geroscience
Jul 2024
Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice
Heliyon
Nov 2023
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
iScience
Mar 2023
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease
Glia
Dec 2022
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis
Cell Metab
Nov 2022
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
PLoS One
Apr 2022
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease
Matrix Biol
Aug 2021
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
Commun Biol
Mar 2021
Novel compounds with dual S1P receptor agonist and histamine H 3 receptor antagonist activities act protective in a mouse model of multiple sclerosis
Neuropharmacology
Jan 2021
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res
Feb 2020
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy
Nat Commun
Feb 2019
Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases
Mol Ther
May 2018
Distinctive Roles for a7 - and a9 -Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis
Front Cell Neurosci
Sep 2017
Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background.
Front Neurosci
Sep 2017
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Sci Rep
Jun 2017
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Nature
Mar 2017
Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis
J Am Coll Cardiol
Dec 2016
Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing
J Comp Neurol
Sep 2016
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
Proc Natl Acad Sci U S A
Sep 2016
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.
Nature
Sep 2016
Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock–induced oxidation
FASEB J
Jun 2016
Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system.
J Appl Physiol
Jun 2016
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma Raymond G.
Nature
May 2016
Impairment of PARK14-dependent Ca2 þ signalling is a novel determinant of Parkinson’s disease.
Nat Commun
Feb 2016
Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival
PLoS One
Jan 2016
Infiltration of CCR2+Ly6Chigh Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis
J Immunol
Jan 2016
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance toFTY720 but not ST-968 treatments.
Neuropharmacology
Jan 2016
Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-induced Expression of RANKL.
Endocrinology
Dec 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nat Commun
Dec 2015
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
PLoS One
Nov 2015
Deletion of the Distal Tnfsf11 RL-D2 Enhancer that Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice.
J Bone Miner Res
Oct 2015
Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation
Mol Genet Genomic Med
Oct 2015
NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.
Free Radic Biol Med
Aug 2015
Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner
Proc Natl Acad Sci U S A
May 2015
Effect of light on global gene expression in the neuroglobin-deficient mouse retina
Biomedical Reports
Apr 2015
CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.
Chem Senses
Jan 2015
The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.
Am J Physiol Regul Integr Comp Physiol
Nov 2014
Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
Mol Vis
Nov 2014
Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin.
Int J Obes (Lond)
Sep 2014
Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.
ACS Chem Neurosci
Aug 2014
DRAGO (KIAA0247), a New DNA Damage-Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosupprossor.
J Natl Cancer Inst
Jun 2014
The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.
Exp Neurol
May 2014
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
J Vis Exp
May 2014
Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin
J Appl Physiol (1985)
Mar 2014
Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice
PLoS One
Feb 2014
Helicase-like transcription factor (hltf) regulates g2/m transition, wt1/gata4/hif-1a cardiac transcription networks, and collagen biogenesis.
PLoS One
Dec 2013
Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low fat contents
Biochimie
Nov 2013
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
J Biol Chem
Sep 2013
Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice
Diabetologia
Aug 2013
Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
PLoS One
Jun 2013
Disruption of the histidine triad nucleotide‐binding hint2 gene in mice affects glycemic control and mitochondrial function
Hepatology
May 2013
Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease.
J Lipid Res
May 2013
Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis
Circulation
Apr 2013
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.
Nature
Mar 2013
Differential modulation of EAE by α9-and β2-nicotinic acetylcholine receptors
Immunol Cell Biol
Mar 2013
XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation.
J Biol Chem
Jan 2013
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
Mol Cell
Jan 2013
Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism
PLoS One
Nov 2012
Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/⁺Gr-1⁺ myeloid cells--brief report
Arterioscler Thromb Vasc Biol
Nov 2012
Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Stem Cells
Nov 2012
Cellular ageing, increased mortality and FTLD‐TDP‐associated neuropathology in progranulin knockout mice
J Pathol
Sep 2012
Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase
Biochem Biophys Res Commun
Aug 2012
The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
EMBO J
Aug 2012
Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.
Proc Natl Acad Sci U S A
Jul 2012
Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency
Proc Natl Acad Sci U S A
Jun 2012
The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility.
Mol Endocrinol
Jun 2012
Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity
J Neurochem
Jun 2012
Neuroglobin-Deficiency Exacerbates Hif1A and c-FOS Response, but Does Not Affect Neuronal Survival during Severe Hypoxia In Vivo
PLoS One
Dec 2011
Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)
J Neurosci
Nov 2011
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
Proc Natl Acad Sci U S A
Nov 2011
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
Proc Natl Acad Sci U S A
Oct 2011
A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver
Biochimie
May 2011
Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival
J Biol Chem
Apr 2011
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
J Biol Chem
Feb 2011
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
Proc Natl Acad Sci U S A
Jan 2011
Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1
J Biol Chem
Dec 2010
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