Conditional Knockout mice

Our off-the-shelf conditional Knockout models are well-established, validated and widely used mouse lines.

FGF21

|

Fibroblast growth factor 21

Synonyms:

Fibroblast growth factor 21

Gene ID (NCBI):

56636

Protein function:

Regulates glucose and lipid metabolism, especially under fasting conditions.

Applications:

Metabolic and diabetes research.

Tlr9

|

Toll-like receptor 9

Synonyms:

Toll-like receptor 9

Gene ID (NCBI):

24088

Protein function:

Plays a role in pathogen recognition and activation of innate immunity.

Applications:

Autoimmunity and pathogen recognition research.

Klk5

|

Kallikrein-related peptidase 5

Synonyms:

Kallikrein-related peptidase 5

Gene ID (NCBI):

234779

Protein function:

Involved in skin desquamation and barrier function.

Applications:

Skin barrier and dermatology research.

mir142

|

MicroRNA 142

Synonyms:

MicroRNA 142

Gene ID (NCBI):

387059

Protein function:

Regulates gene expression, especially in immune cells.

Applications:

Gene regulation and immune research.

Usp30

|

Ubiquitin specific peptidase 30

Synonyms:

Ubiquitin specific peptidase 30

Gene ID (NCBI):

333786

Protein function:

Involved in mitochondrial quality control via ubiquitination pathways.

Applications:

Mitochondrial research and neurodegeneration models.

IL-17a/IL-17f

|

Interleukin 17A/F

Synonyms:

Interleukin-17A/F

Gene ID (NCBI):

257642

Protein function:

Involved in immune response, particularly in promoting inflammation.

Applications:

Autoimmunity and inflammation research.

Rbm24

|

RNA binding motif protein 24

Synonyms:

RNA binding motif protein 24

Gene ID (NCBI):

237911

Protein function:

Plays a role in muscle cell differentiation and maintenance.

Applications:

Muscle differentiation and development research.

IL17f

|

Interleukin 17F

Synonyms:

Interleukin-17F

Gene ID (NCBI):

257630

Protein function:

Involved in immune response, particularly in inflammation and autoimmune diseases.

Applications:

Inflammatory and autoimmune disease research.

cmtm4

|

CKLF-like MARVEL transmembrane domain containing 4

Synonyms:

CKLF-like MARVEL transmembrane domain containing 4

Gene ID (NCBI):

240640

Protein function:

Involved in immune response and cell membrane stability.

Applications:

Cancer and immune signaling research.

Cmtm6

|

CKLF-like MARVEL transmembrane domain containing 6

Synonyms:

CKLF-like MARVEL transmembrane domain containing 6

Gene ID (NCBI):

227399

Protein function:

Modulates PD-L1 expression in immune cells.

Applications:

Immune checkpoint and cancer research.

Tom1

|

Target of Myb1

Synonyms:

Target of Myb1

Gene ID (NCBI):

231288

Protein function:

Involved in endosomal sorting and intracellular signaling pathways.

Applications:

Endosomal function and cellular signaling studies.

Hsd17b13

|

Hydroxysteroid 17-beta dehydrogenase 13

Synonyms:

Hydroxysteroid 17-beta dehydrogenase 13

Gene ID (NCBI):

225998

Protein function:

Involved in lipid metabolism and steroid hormone regulation.

Applications:

Liver disease and metabolic research.

Nemo

|

NF-kappa-B essential modulator

Synonyms:

IKK-gamma

Gene ID (NCBI):

170760

Protein function:

Regulates NF-kappa-B signaling, critical for immune responses.

Applications:

Studies on NF-kappa-B signaling, immune response.

Clec9a

|

C-type lectin domain family 9 member A

Synonyms:

C-type lectin domain family 9 member A

Gene ID (NCBI):

71946

Protein function:

Involved in antigen presentation and immune response.

Applications:

Antigen presentation and immunology research.

Tmem97

|

Transmembrane protein 97

Synonyms:

Sigma-2 receptor

Gene ID (NCBI):

69071

Protein function:

Involved in cellular stress response and lipid metabolism.

Applications:

Cancer and neurodegeneration research.

Lyve1

|

Lymphatic vessel endothelial hyaluronan receptor 1

Synonyms:

Lymphatic vessel endothelial hyaluronan receptor 1

Gene ID (NCBI):

64320

Protein function:

Involved in lymphatic endothelial cell function and hyaluronan binding.

Applications:

Lymphatic function and lymphedema research.

Adgra3

|

Adhesion G protein-coupled receptor A3

Synonyms:

Adhesion G protein-coupled receptor A3

Gene ID (NCBI):

69219

Protein function:

Plays a role in cell adhesion and immune signaling.

Applications:

Immune response and cell signaling research.

Kcnv2

|

Potassium channel subfamily V member 2

Synonyms:

Potassium channel subfamily V member 2

Gene ID (NCBI):

64145

Protein function:

Regulates potassium ion transport in retinal cells.

Applications:

Retinal research and ion transport studies.

Vps4a

|

Vacuolar protein sorting 4A

Synonyms:

Vacuolar protein sorting 4A

Gene ID (NCBI):

56314

Protein function:

Involved in endosomal trafficking and cellular sorting processes.

Applications:

Cellular sorting and neurodegeneration research.

Il4i1

|

Interleukin 4 induced 1

Synonyms:

Interleukin 4-induced 1

Gene ID (NCBI):

54126

Protein function:

Modulates immune response, particularly under IL-4 influence.

Applications:

Inflammation and immune response studies.

Brk1

|

BRICK1

Synonyms:

BRICK1

Gene ID (NCBI):

51885

Protein function:

Involved in actin cytoskeleton organization.

Applications:

Cell motility and cancer metastasis research.

Gpr84

|

G protein-coupled receptor 84

Synonyms:

G protein-coupled receptor 84

Gene ID (NCBI):

26896

Protein function:

Involved in immune response and inflammation.

Applications:

Inflammation and metabolic disease research.

Vsig4

|

V-set and immunoglobulin domain containing 4

Synonyms:

V-set and immunoglobulin domain containing 4

Gene ID (NCBI):

27988

Protein function:

Acts as a macrophage-specific complement receptor, modulating immune response.

Applications:

Autoimmune and macrophage function studies.

GIGYF1

|

Grb10 interacting GYF protein 1

Synonyms:

Grb10 interacting GYF protein 1

Gene ID (NCBI):

23829

Protein function:

Involved in growth factor receptor signaling, affecting cell growth and insulin response.

Applications:

Diabetes and growth factor research.

CD40

|

CD40 molecule

Synonyms:

TNFRSF5, Bp50

Gene ID (NCBI):

21939

Protein function:

Involved in immune responses via B-cell activation.

Applications:

Models for immunotherapy and autoimmune disease.

Tec

|

TEC protein tyrosine kinase

Synonyms:

TEC

Gene ID (NCBI):

21682

Protein function:

Involved in T-cell and B-cell signaling pathways.

Applications:

Studies on immune signaling and lymphocyte function.

Smn1

|

Survival of motor neuron 1

Synonyms:

Survival of motor neuron 1

Gene ID (NCBI):

20563

Protein function:

Essential for motor neuron survival and function.

Applications:

Neurological and motor neuron disease research.

Srd5a2

|

Steroid 5 alpha-reductase 2

Synonyms:

Steroid 5 alpha-reductase 2

Gene ID (NCBI):

20720

Protein function:

Involved in steroid metabolism, converting testosterone to dihydrotestosterone.

Applications:

Androgen metabolism and endocrine research.

Psgl1

|

Selectin P ligand

Synonyms:

Selplg, CD162, PSGL-1

Gene ID (NCBI):

20345

Protein function:

Mediates leukocyte rolling on activated endothelium, essential for immune cell migration.

Applications:

Used in inflammation and immune response models.

Atxn2

|

Ataxin 2

Synonyms:

Ataxin-2

Gene ID (NCBI):

20226

Protein function:

Involved in RNA processing and associated with neuronal function.

Applications:

Neurodegeneration and ataxia research.

Ptger4

|

Prostaglandin E receptor 4

Synonyms:

EP4

Gene ID (NCBI):

19219

Protein function:

Mediates response to prostaglandin E2, involved in immune modulation.

Applications:

Models for inflammation, pain response, and immune modulation.

Psen2

|

Presenilin 2

Synonyms:

Presenilin-2, PS2

Gene ID (NCBI):

19165

Protein function:

Involved in amyloid precursor protein processing, relevant to Alzheimer's pathogenesis.

Applications:

Alzheimer’s disease and neurodegeneration models.

Pkd1

|

Polycystic kidney disease 1

Synonyms:

Polycystic kidney disease 1

Gene ID (NCBI):

18760

Protein function:

Involved in kidney development and function.

Applications:

Kidney disease and cystogenesis research.

Pgf

|

Placental growth factor

Synonyms:

Placental growth factor

Gene ID (NCBI):

18654

Protein function:

Promotes angiogenesis, especially during placental development.

Applications:

Angiogenesis and placental development research.

PD-1

|

Programmed cell death 1

Synonyms:

Programmed cell death protein 1

Gene ID (NCBI):

18566

Protein function:

Regulates immune response by inhibiting T-cell activity.

Applications:

Cancer immunotherapy and autoimmunity research.

Notch3

|

Notch homolog 3

Synonyms:

Notch homolog 3

Gene ID (NCBI):

18131

Protein function:

Regulates cell differentiation and signaling pathways.

Applications:

Vascular and cell differentiation research.

CD138

|

Syndecan 1

Synonyms:

Syndecan-1

Gene ID (NCBI):

17113

Protein function:

Mediates cell adhesion and plays a role in immune response.

Applications:

Cancer research, particularly myeloma studies.

MAPT

|

Microtubule-associated protein tau

Synonyms:

Tau, Microtubule-associated protein tau

Gene ID (NCBI):

17762

Protein function:

Stabilizes microtubules in neurons, crucial for neuron structure and function.

Applications:

Alzheimer’s and neurodegeneration research.

Smad3

|

SMAD family member 3

Synonyms:

Mothers against decapentaplegic homolog 3, Mad3

Gene ID (NCBI):

17128

Protein function:

Regulates cell growth, differentiation, and apoptosis in TGF-beta signaling pathway.

Applications:

TGF-beta signaling, cancer, and fibrosis research.

Kiss1

|

Kisspeptin

Synonyms:

Kisspeptin

Gene ID (NCBI):

16854

Protein function:

Regulates puberty and reproductive hormone release.

Applications:

Reproductive development and hormone regulation research.

GAL3

|

Galectin 3

Synonyms:

LGALS3, Galectin-3

Gene ID (NCBI):

16854

Protein function:

Involved in cell-cell adhesion, immune response modulation.

Applications:

Cancer, inflammation, and fibrosis studies.

Ldhb

|

Lactate dehydrogenase B

Synonyms:

Lactate dehydrogenase B

Gene ID (NCBI):

16829

Protein function:

Catalyzes conversion of lactate to pyruvate in metabolic processes.

Applications:

Metabolism and energy research.

Gabrd

|

Gamma-aminobutyric acid receptor subunit delta

Synonyms:

Gamma-aminobutyric acid receptor subunit delta

Gene ID (NCBI):

14406

Protein function:

Mediates inhibitory neurotransmission in the central nervous system.

Applications:

Epilepsy and anxiety research.

Jchain

|

Joining chain of multimeric IgA and IgM

Synonyms:

Joining chain of multimeric IgA and IgM

Gene ID (NCBI):

16450

Protein function:

Involved in IgA and IgM antibody assembly and immune response.

Applications:

Antibody and immune response research.

Klk7

|

Kallikrein-related peptidase 7

Synonyms:

Kallikrein-related peptidase 7

Gene ID (NCBI):

16620

Protein function:

Plays a role in skin desquamation and barrier maintenance.

Applications:

Skin research, barrier function studies.

Grn

|

Granulin

Synonyms:

Granulin, Progranulin

Gene ID (NCBI):

14824

Protein function:

Plays a role in inflammation, cell growth, and wound repair.

Applications:

Neurodegeneration and cancer research.

Il18rap

|

Interleukin 18 receptor accessory protein

Synonyms:

Interleukin 18 receptor accessory protein

Gene ID (NCBI):

16172

Protein function:

Involved in immune response modulation, specifically in IL-18 signaling.

Applications:

Autoimmunity and cytokine signaling studies.

FST

|

Follistatin

Synonyms:

Follistatin

Gene ID (NCBI):

14313

Protein function:

Regulates growth and differentiation by binding and neutralizing activins.

Applications:

Growth and muscle development studies.

Ephx2

|

Epoxide hydrolase 2

Synonyms:

Soluble epoxide hydrolase

Gene ID (NCBI):

13850

Protein function:

Involved in the metabolism of epoxides in the body, affecting inflammation and vascular function.

Applications:

Cardiovascular and inflammation research.

DSP1

|

Desmoplakin

Synonyms:

Desmoplakin

Gene ID (NCBI):

13510

Protein function:

Structural protein critical for cell-cell adhesion in desmosomes.

Applications:

Skin integrity and cell adhesion research.

Dlg4

|

Discs large homolog 4

Synonyms:

Discs large homolog 4

Gene ID (NCBI):

13385

Protein function:

Involved in synaptic signaling and neural connectivity.

Applications:

Neurodevelopmental disorder research.

DLL3

|

Delta-like protein 3

Synonyms:

Delta-like 3

Gene ID (NCBI):

13208

Protein function:

Involved in Notch signaling pathway, regulating cell differentiation.

Applications:

Developmental and cancer research.

Csf2ra

|

Colony stimulating factor 2 receptor, alpha

Synonyms:

Colony stimulating factor 2 receptor, alpha

Gene ID (NCBI):

12981

Protein function:

Involved in hematopoiesis and immune cell signaling.

Applications:

Hematopoiesis and immune response research.

Coch

|

Cochlin

Synonyms:

Cochlin

Gene ID (NCBI):

12860

Protein function:

Involved in inner ear function and associated with hearing.

Applications:

Hearing loss and cochlear research.

CD33

|

CD33 molecule

Synonyms:

Siglec-3

Gene ID (NCBI):

12489

Protein function:

Involved in immune system regulation and signaling.

Applications:

Alzheimer's and immune system research.

CDK2

|

Cyclin-dependent kinase 2

Synonyms:

Cdc2-related protein kinase, p33cdk2

Gene ID (NCBI):

12566

Protein function:

Critical role in cell cycle regulation, especially transition from G1 to S phase.

Applications:

Cancer and cell cycle research.

CCR8

|

C-C motif chemokine receptor 8

Synonyms:

C-C chemokine receptor type 8

Gene ID (NCBI):

12776

Protein function:

Involved in immune cell trafficking, especially in T-helper cell responses.

Applications:

Asthma and inflammatory disease research.

Ccr4

|

C-C motif chemokine receptor 4

Synonyms:

C-C motif chemokine receptor 4

Gene ID (NCBI):

12774

Protein function:

Involved in T-cell trafficking, particularly in regulatory T cells.

Applications:

Allergy and T-cell research.

CD38

|

CD38 molecule

Synonyms:

Cyclic ADP ribose hydrolase

Gene ID (NCBI):

12494

Protein function:

Involved in calcium signaling and immune cell function.

Applications:

Leukemia and immune function studies.

Cblb

|

Casitas B-lineage lymphoma proto-oncogene-b

Synonyms:

Casitas B-lineage lymphoma proto-oncogene-b

Gene ID (NCBI):

12402

Protein function:

Involved in regulating immune response and T-cell activation.

Applications:

Autoimmunity and immune regulation research.

BTK

|

Bruton's tyrosine kinase

Synonyms:

Bruton's tyrosine kinase

Gene ID (NCBI):

12142

Protein function:

Critical for B-cell development and function.

Applications:

Immunodeficiency and B-cell pathway studies.

Bmpr2

|

Bone morphogenetic protein receptor type 2

Synonyms:

Bone morphogenetic protein receptor type 2

Gene ID (NCBI):

12154

Protein function:

Regulates cell growth and differentiation, particularly in vascular cells.

Applications:

Vascular disease and bone growth research.

BTK

|

Bruton's tyrosine kinase

Synonyms:

Bruton's tyrosine kinase

Gene ID (NCBI):

12142

Protein function:

Critical for B-cell development and function.

Applications:

Immunodeficiency and B-cell pathway studies.

CD138

|

Syndecan 1

Synonyms:

Syndecan-1

Gene ID (NCBI):

17113

Protein function:

Mediates cell adhesion and plays a role in immune response.

Applications:

Cancer research, particularly myeloma studies.

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Immunodeficient rodents

Explore our immunodeficient models, featuring cutting-edge strains like BRGSF mouse and SDRG rat.

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Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

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Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.

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Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

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Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.