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MC38-hCD39-LZ
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Humanized MC38-hCD39-LZ reporter tumor cell line

The  MC38-hCD39-LZ cells homogeneously express human CD39 in vitro, and form  infiltrated tumors in immunocompetent mice.

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Design of the MC38-hCD39-LZ cell line

The MC38 cell line was derived from C57BL/6 murine colon adenocarcinoma cells. They form solid tumors upon subcutaneous injection in immunocompetent mice.

We generated an MC38-hCD39-LZ clonal cell line expressing high levels of human CD39 (ENTPD1 NCBI GeneID: 953), and an optimized dual fusion reporter, luciferase-ZsGreen (LZ). MC38-hCD39-LZ cells form solid tumors in vivo. Isogenic luciferase-ZsGreen (LZ) cells are available.

This cell line can be used in syngeneic models with our hCD39 mouse model.

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MC38-hCD39-LZ features

  • Express a chimeric CD39, with a humanized extracellular domain
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form tumors upon subcutaneous injection in fully immunocompetent mice

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Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Front Immunol

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CCX559 is a potent orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

PLoS One

Jan 2023
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ERα-36 regulates progesterone receptor activity in breast cancer

Breast Cancer Res

Jan 2020
T cells expressing a chimeric-PD1-Dap10-CD3zeta receptor reduce tumor burden in multiple murine syngeneic models of solid cancer

Immunology

Jan 2020
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.

Nat Immunol

Jan 2019
Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF

Cancer Immunol Res

Jan 2019
Development of a new hSIRPα-specific radiotracer for non-invasive PET imaging using genOway’s double humanized hCD47/hSIRPα mouse and MC38-hPD-L1-hCD47-LZ cell line

Targeting the human CD47/SIRPα axis

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Mar 2024
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