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EL4-hCD20-LZ
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Humanized EL4-hCD20-LZ reporter tumor cell line

The  EL4-hCD20-LZ clonal cell line expresses high levels of human CD20.

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Design of the EL4-hCD20-LZ cell line

The EL-4 cell line was established from a C57BL/6 murine lymphoma. These cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice.

We generated an EL4-hCD20-LZ clonal cell line expressing high levels of human CD20 (MS4A1 NCBI GeneID: 931), and an optimized dual fusion reporter luciferase-ZsGreen (LZ). EL4-hCD20-LZ cells form tumors in vivo when injected systemically. Luciferase-ZsGreen (LZ) control cells are available.

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EL4-hCD20-LZ features

  • Express a fully human CD20
  • Express a luciferase-ZsGreen (LZ) fusion reporter
  • Form tumors and impact survival upon systemic injection in fully immunocompetent mice
  • Luciferase from injected cells can be detected by in vivo imaging

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Humanized EL4-hCD20-LZ reporter tumor cell line

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