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Applications of the genO‑hTFRC mouse model
Useful applications for researchers working on different biomedical fields, such as neuroscience, immuno-oncology and inflammation:
- Improve the delivery of therapeutic agents aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (TFRC) binding and test their efficacy
- Assess the efficacy of immunotherapies in cancers that overexpress TFRC (CD71, TfR1)
- Evaluate the in vivo PK profile and toxicity of TFRC-binding therapeutics
Features
- Physiological regulation and expression pattern of human TFRC
- Lack of expression of the murine target gene
- Fully functional mouse immune system
- Available on C57BL/6N genetic background
Clients
