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hTFRC
Humanized mice (target-specific)

Preclinical humanized TFRC mouse model

The fully immunocompetent hTFRC mouse model enables in vivo efficacy assessment and profiling of compounds targeting human TFRC (CD71, TfR1) and aiming to deliver therapeutic agents through the blood brain barrier.

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Applications of the hTFRC mouse model

Useful applications for researchers working on different biomedical fields, such as neuroscience, immuno-oncology and inflammation:

  • Improve the delivery of therapeutic agents aiming to cross the blood-brain barrier (BBB), via human transferrin receptor (TFRC) binding and test their efficacy
  • Assess the efficacy of immunotherapies in cancers that overexpress TFRC (CD71, TfR1)
  • Evaluate the in vivo PK profile and toxicity of TFRC-binding therapeutics

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Features

  • Physiological regulation and expression pattern of human TFRC
  • Lack of expression of the murine target gene
  • Fully functional mouse immune system
  • Available on C57BL/6N genetic background

Clients

Lundbeck

Scientific articleScientific articlePosterPoster

Related resources and publications

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

pain research

nutrition

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

schizophrenia

Senescence-associated secretory phenotype (SASP)

seizure

sarcoidosis

rhesus-deficiency syndrome

retinopathy

retinitis pigmentosa (RP)

retinal dystrophy disorder

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Novel TFRC humanized mouse model for drug delivery to the brain

Drug delivery to the brain (TFRC)

Apr 2024
INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment

Mol Cancer Ther

Apr 2024
Highlighted article
read the comment
Development of a new antibody-drug conjugate against CD71, INA03, for the treatment of leukemia

TFRC for anti-cancer therapies

8 min read
-
Jul 2024
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Preclinical humanized TFRC mouse model

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