Applications of the BRGSF-HIS mouse model

The BRGSF-HIS mouse model can address a broad spectrum of therapeutic areas and applications, including bispecific antibodies, immuno-oncology, infectiology, vaccines, drug screening, and personalized medicine.

  • ‍Application in tumor biology:
    • Assessment of myeloid and lymphoid human cells recruitment and activation profile into the tumor microenvironment (TME) shaped by tumor cell type and tumor burden
  • ‍Application in efficacy assessment of:
    • T-cell engagers
    • Myeloid-targeted therapies aiming at reprogramming the TME
    • Depleting agents working via ADCP and ADCC
    • γδ T-cell expanders, as the model has shown to develop different subsets of γδ T cells
  • ‍Application in safety assessment of:‍
    • Anti-CD3 OKT3 antibody which targets the lymphoid and/or myeloid compartments, demonstrating the development of the hallmark features of cytokine release syndrome, as well as CRS-associated features induced by T-cell or myeloid targeting agents. The OKT3-induced CRS features could be alleviated by Infliximab
    • Anti-VISTA pH-selective antibody, showing the safety of SNS-101 therapeutic antibody
Show product

Validation

BRGSF-HIS mouse model - humanized for immune system

Get in touch about

Let us know how we can help

In order to provide you the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please tick the checkbox below.

From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please tick below.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.