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Humanized mice (target-specific)
Preclinical humanized GLP-1R mouse model
Preclinical hGLP-1R model for assessment of agents targeting human GLP-1R
Applications of hGLP-1R
hGLP-1R allows for efficacy assessment of human GLP-1R-targeting compounds in various fields, such as autoimmune diseases and metabolic disorders.
hGLP-1R features
- The GLP-1R mature protein is entirely human, thus enabling assessment of human-specific compounds
- Physiological regulation and expression pattern of the human GLP-1R
- Fully functional hGLP-1R
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Validation
Human GLP-1R expression pattern in brain, liver and lung recapitulates mGlp-1r
hGLP-1R and mGlp-1r expression assessed in brain, liver and lung of WT and hGLP-1R mice by RT-qPCR.
In vivo, DNG human-specific agonist improve glucose tolerance in hGLP-1R mice
Blood glucose was monitored every 30 minutes.
DNG efficiently decreases circulating glucose in hGLP-1R model.
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hGLP-1R
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Preclinical humanized GLP-1R mouse model
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