Applications of the hGLP-1R mouse model

Broad range of applications in the fields of metabolism, autoimmunity and neuroscience:

  • Assess the efficacy of GLP-1R targeting compounds, such as in the context of treating type 2 diabetes and obesity
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

Features

  • Physiological regulation and expression of the humanized GLP-1R
  • Fully functional hGLP-1R
  • Lack of expression of the murine target gene
  • Model is available in a C57BL/6N background
  • Fully functional mouse immune system

Related resources and publications

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Validation data

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Preclinical humanized GLP-1R mouse model

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