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hGLP-1R
Humanized mice (target-specific)

Preclinical humanized GLP-1R mouse model

Preclinical hGLP-1R model for assessment of agents targeting human GLP-1R

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Applications of the hGLP-1R mouse model

Broad range of applications in the fields of metabolism, autoimmunity and neuroscience:

  • Assess the efficacy of GLP-1R targeting compounds, such as in the context of treating type 2 diabetes and obesity
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

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Features

  • Physiological regulation and expression of the humanized GLP-1R
  • Fully functional hGLP-1R
  • Lack of expression of the murine target gene
  • Model is available in a C57BL/6N background
  • Fully functional mouse immune system

Clients

Pfizer

Scientific articleScientific articlePosterPoster

Related resources and publications

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Scientific Articles
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Case studies
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No results
Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial

Nat Med

Jul 2021
No results
The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R

Physiological relevancy in preclinical models

4 min read
-
Sep 2021
No results

Validation data

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Preclinical humanized GLP-1R mouse model

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