Mouse model generation

Tailored mouse models for accurate predictions, drawing on our 25 years of experience.

Why use a customized mouse model?

Customized mouse models stand at the forefront of precision research, offering tailor-made solutions to address the specific needs of scientific inquiry.

Leveraging state-of-the-art genetic engineering techniques, these models can be precisely modified to include gene Knockouts, Knockins, point mutations, or conditional alleles, allowing researchers to investigate the function of specific genes or pathways.

With a commitment to flexibility and scientific excellence, we empower researchers with the ability to design and create mouse models that closely mimic human conditions, fostering groundbreaking discoveries across various fields, from basic biology to preclinical drug development. Whether the goal is to study disease mechanisms, assess therapeutic targets, or validate drug candidates, we provide a versatile and reliable platform for advancing scientific understanding and driving innovation.

Our services for

Mouse model generation

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Customized mouse

Quick KI mouse

The Rosa26 and Hprt gene loci are well suited for gene over-expression, reduced development time and cost with ready-to-use targeting vectors.

Customized mouse

Reporter KI mouse

Use a reporter mouse Knockin for in vivo monitoring of transcriptional promoter activity, protein localization, cell trafficking, etc.

Customized mouse

Point mutation KI mouse

Use a point mutation mouse Knockin to circumvent complex phenotypes arising from complete Knockouts (e.g., signaling pathway problems, cross-reactivity).

Customized mouse

Humanized KI mouse

Use humanized mice as in vivo tools for mimicking human pathological conditions and diseases, and for conducting preclinical research.

Customized mouse

Protein function KO mouse

A protein function Knockout mouse defines a model in which one or more nucleotides are mutated in a way that the protein loses its function.

Customized mouse

Constitutive KO mouse

A constitutive, conventional, or whole-body Knockout mouse is a fast and cost-effective solution for in vivo preliminary studies of target gene functions.

Customized mouse

Time-dependent KO mouse

Use an inducible conditional Knockout mouse to age-dependently inactivate your gene, and to enable studies at defined development stages or on age-related diseases.

Customized mouse

Tissue-specific KO mouse

Use tissue- or cell-specific conditional Knockout mouse models to bypass embryonic lethality, compensatory mechanisms, complex phenotypes, etc.

Related ressources et publication

pulmonary embolism (PE)

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

nutrition

pain research

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

schizophrenia

Senescence-associated secretory phenotype (SASP)

seizure

sarcoidosis

rhesus-deficiency syndrome

retinopathy

retinitis pigmentosa (RP)

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No results

EBP1 potentiates amyloid β pathology by regulating γ-secretase

Nat Aging

NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control

Cancer Immunol Res

Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling

Nat Commun

GalNT2-mediated O-glycosylation affects pancreas development and function in mice

Sci Rep

NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Biomaterials

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Theranostics

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Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993

Eur J Nucl Med Mol Imaging

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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

Geroscience

Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

Invest Ophthalmol Vis Sci

Missense mutation (C667F) in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization

Dis Model Mech

An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

Sci Transl Med

A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia

Sci Rep

Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution

JCI Insight

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression

Mol Cancer Ther

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Nat Neurosci

HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors

Mol Cancer Ther

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Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells

J Am Soc Nephrol

Fitusiran reduces bleeding in Factor X-deficient mice

Blood

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Nat Commun

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Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia

Neurobiol Dis

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas

Hum Mol Genet

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Nat Cardiovasc Res

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

Nat Commun

Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Front Immunol

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Nat Commun

An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies

Front Immunol

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Front Immunol

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function

Cell Death Dis

Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

JBMRplus

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Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9

Hear Res

Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of HDL and LDL in opposite ways

Cardiovasc Res

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Front Immunol

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Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

Cell Mol Life Sci

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion

J Lipid Res

Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice

PLoS One

Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice

PLoS One

Detecting Central Auditory Processing Disorders in Awake Mice

Brain Science

Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

Glia

Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

EMBO Rep

Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment

Proc Natl Acad Sci U S A

The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma

Cancer Res

Taurine depletion impairs cardiac function and affects tolerance to hypoxia and high temperatures in brook char (Salvelinus fontinalis)

J Exp Biol

SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties

Immunohorizons

Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer

Cancer Cell

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Nat Commun

Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events

Kidney Int

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia

Autophagy

NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

iScience

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Nat Commun

Neoadjuvant immunotherapy for melanoma is now ready for clinical practice

Nat Med

NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer

Cancers (Basel)

Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning

Int J Mol Sci

Multilineage commitment of Sca-1+ cells in reshaping vein grafts

Theranostics

Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

Cell Rep Med

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

FASEB J

Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice

Heliyon

IgG against the membrane-proximal portion of the desmoglein 3 ectodomain induces loss of keratinocyte adhesion, a hallmark in pemphigus vulgaris

J Invest Dermatol

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells

J Allergy Clin Immunol

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

PLoS One

Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes

Life Sci Alliance

Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion

JCI Insight

Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features

Am J Respir Cell Mol Biol

Cathepsin D overexpression in the nervous system rescues lethality and Ab42 accumulation of cathepsin D systemic knockout in vivo

Acta Pharm Sin B

Brain-derived Estrogen: A Critical Player in Maintaining Cognitive Health of Aged Female Rats, Possibly Involving GPR30

Neurobiol Aging

Biodistribution and function of coupled polymer-DNA origami nanostructures

Sci Rep

A gain-of-function filamin A mutation in mouse platelets induces thrombus instability

J Thromb Haemost

Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death

Redox Biol

The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Pancreatology

Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity

iScience

JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

Cell Rep

Hyaluronan Synthase 3 is Protective After Cardiac Ischemia-Reperfusion by preserving the T cell Response

Matrix Biol

Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice

Cell Rep

An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn’s disease

Dis Model Mech

TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy

Neurobiol Dis

ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways

Biol Trace Elem Res

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

J Immunother Cancer

R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System

Int J Mol Sci

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

PLoS One

Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response

Nat Cardiovasc Res

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Cell Metab

Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading

Int J Mol Sci

Premature aging in mice with error-prone protein synthesis

Sci Adv

Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia

Mol Cancer

Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH

Biochim Biophys Acta Mol Basis Dis

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Nat Commun

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Nat Commun

KCC2 drives chloride microdomain formation in dendritic blebbing

Cell Rep

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Sci Rep

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Enhanced half-life and antitumor activity of Interleukin-15 through genetic fusion of a serum albumin-specific protein binder

Int J Pharmac

Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice

Nat Commun

DLL3 regulates Notch signaling in small cell lung cancer

iScience

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Breast Cancer Res

Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice

Mol Psychiatry

Cardiac investigations in sudden unexpected death in DEPDC5-related epilepsy

Ann Neurol

Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis

Prog Neurobiol

Apelin controls emotional behavior in age- and metabolic state-dependent manner

Psychoneuroendocrinology

An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy

Nat Cancer

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6 good reasons to employ our repository Knockout mouse models in your in vivo studies

Eucomm conditional Knockouts

A new Nature report by Bristol-Myers Squibb provides new insights into VISTA biology and design of combination therapies

Humanized ICP in immuno-oncology

A finely tuned crosstalk between enteric neurons and muscularis macrophages: evidence from a conditional Knockout mouse model developed by genOway

Customized mouse model

A VISTA on naive T cell fate

Humanized ICP mouse

HSC-derived cell fate tracking

Customized mouse model

A Knockin C3-reporter mouse model represents a valuable tool to monitor C3 levels, a biomarker of inflamed versus uninflamed tissues

Customized mouse model

Define “humanized”: two mouse models helping produce cancer immunotherapies

Humanized mouse models

A novel preclinical and translational humanized CD3ε model to study the efficacy of T-cell engagers

T-cell engager

Uncoupling toxicity from therapeutic efficacy: the new challenge of immunotherapies

Assess toxicity with ICP

New doors to potential novel treatments for obesity

Customized mouse model

Tumor grafts in preclinical research: Models, models, overall, who is the fittest of them all?

Tumor-graft models

Cytokine release syndrome (CRS)

Assess T-cell engager in BRGSF-HIS

A human-specific modifier of cortical connectivity and circuit function

Customized mouse model

NOTUM as alternative therapeutic approach to prevent clonal fixation and mutant expansion in patients predisposed to colorectal cancer

Customized mouse model

Immunotherapy efficacy assessment and metastases studies: tHIS model is highly permissive to engraftment

Engraftments in BRGSF-HIS

Relevant preclinical models to test T-cell engagers: The case of CD28

T-cell engager

An alternative approach to immunotherapy: A bispecific agonist

Humanized PD-1 & GITR mouse

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

T-cell engager CD3

Targeting tumor-associated myeloid cells: The new grail in immuno-oncology?

Myeloid compartment in immuno-oncology

Challenging the predictability of preclinical models for assessment of T-cell engagers

Assess T-cell engager in BRGSF-HIS

Assessing T-cell engagers in vivo: How BRGSF-HIS mice can help

Assess T-cell engager in BRGSF-HIS

Functional human myeloid compartment in BRGSF-HIS preclinical model

Myeloid compartment in BRGSF-HIS

An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Humanized HSA/hFcRn mouse

Expression of druggable myeloid targets in the BRGSF-HIS preclinical model

Myeloid compartment in BRGSF-HIS

Assessing T-cell engagers efficacy in vivo: Versatility of BRGSF-HIS mice

Assess T-cell engager in BRGSF-HIS

Targeting myeloid cells in the tumor microenvironment in BRGSF-HIS mice

Myeloid compartment in BRGSF-HIS

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Humanized VISTA mouse & Pharmacokinetics

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

CRS in BRGSF-HIS

Homeostasis of monocytes and lung interstitial macrophages is regulated by collagen domain-binding receptor LAIR1 in vivo

Myeloid compartment in BRGSF-HIS

Immunocompromised human serum albumin/human neonatal Fc receptor mouse model: A new xenograft model for efficacy studies of immunotherapies

Therapeutic efficacy and pharmacokinetics

Predictive in vivo evaluation of immunotherapy efficacy: tHIS is a reliable model

PDX in BRGSF-HIS

The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R

Physiological relevancy in preclinical models

Deciphering high-dose IL-2 toxicity in reconstituted HIS mice

Immunotherapy in BRGSF-HIS

Uncoupling efficacy from toxicity: a case study on MEDI5752

Bispecific antibodies

Uncoupling toxicity from therapeutic efficacy: a case study on ATOR-1015

Bispecific antibodies

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