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PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451
Biomaterials
Oct 2024
In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy
Theranostics
Aug 2024
Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993
Eur J Nucl Med Mol Imaging
Jul 2024
Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Geroscience
Jul 2024
Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia
Invest Ophthalmol Vis Sci
Jun 2024
Missense mutation (C667F) in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization
Dis Model Mech
Jun 2024
An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva
Sci Transl Med
May 2024
A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia
Sci Rep
May 2024
Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution
JCI Insight
May 2024
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression
Mol Cancer Ther
May 2024
Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin
JCI Insight
May 2024
Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy
Nat Neurosci
May 2024
HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Mol Cancer Ther
Apr 2024
Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells
J Am Soc Nephrol
Apr 2024
VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
Nat Commun
Apr 2024
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia
Neurobiol Dis
Mar 2024
Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas
Hum Mol Genet
Mar 2024
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Nat Cardiovasc Res
Mar 2024
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration
Nat Commun
Mar 2024
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice
Nat Commun
Feb 2024
An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies
Front Immunol
Feb 2024
Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model
Front Immunol
Feb 2024
The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function
Cell Death Dis
Jan 2024
Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice
JBMRplus
Jan 2024
Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9
Hear Res
Dec 2023
Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of HDL and LDL in opposite ways
Cardiovasc Res
Dec 2023
A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors
Front Immunol
Dec 2023
Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain
Cell Mol Life Sci
Nov 2023
A gain-of-function filamin A mutation in mouse platelets induces thrombus instability
J Thromb Haemost
Jan 2023
Brain-derived Estrogen: A Critical Player in Maintaining Cognitive Health of Aged Female Rats, Possibly Involving GPR30
Neurobiol Aging
Jan 2023
Cathepsin D overexpression in the nervous system rescues lethality and Ab42 accumulation of cathepsin D systemic knockout in vivo
Acta Pharm Sin B
Jan 2023
Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features
Am J Respir Cell Mol Biol
Jan 2023
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion
JCI Insight
Jan 2023
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes
Life Sci Alliance
Jan 2023
Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality
PLoS One
Jan 2023
Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells
J Allergy Clin Immunol
Jan 2023
IgG against the membrane-proximal portion of the desmoglein 3 ectodomain induces loss of keratinocyte adhesion, a hallmark in pemphigus vulgaris
J Invest Dermatol
Jan 2023
Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice
Heliyon
Jan 2023
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
Cell Rep Med
Jan 2023
NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer
Cancers (Basel)
Jan 2023
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
Nat Commun
Jan 2023
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
iScience
Jan 2023
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia
Autophagy
Jan 2023
Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events
Kidney Int
Jan 2023
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Nat Commun
Jan 2023
Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer
Cancer Cell
Jan 2023
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties
Immunohorizons
Jan 2023
Taurine depletion impairs cardiac function and affects tolerance to hypoxia and high temperatures in brook char (Salvelinus fontinalis)
J Exp Biol
Jan 2023
Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment
Proc Natl Acad Sci U S A
Jan 2023
Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy
J Allergy Clin Immunol
Jan 2023
Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease
Glia
Jan 2023
Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice
PLoS One
Jan 2023
Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice
PLoS One
Jan 2023
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
Cell Rep
Jan 2022
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
Nat Metab
Jan 2022
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection
Sci Rep
Jan 2022
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD
Acta Neuropathol
Jan 2022
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension
Acta Biomater
Jan 2022
An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy
Nat Cancer
Jan 2022
Apelin controls emotional behavior in age- and metabolic state-dependent manner
Psychoneuroendocrinology
Jan 2022
Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
Prog Neurobiol
Jan 2022
Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer
Breast Cancer Res
Jan 2022
Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice
Nat Commun
Jan 2022
Enhanced half-life and antitumor activity of Interleukin-15 through genetic fusion of a serum albumin-specific protein binder
Int J Pharmac
Jan 2022
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model
Sci Rep
Jan 2022
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
Nat Commun
Jan 2022
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH
Biochim Biophys Acta Mol Basis Dis
Jan 2022
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia
Mol Cancer
Jan 2022
Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading
Int J Mol Sci
Jan 2022
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis
Cell Metab
Jan 2022
Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response
Nat Cardiovasc Res
Jan 2022
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
PLoS One
Jan 2022
R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System
Int J Mol Sci
Jan 2022
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment
J Immunother Cancer
Jan 2022
ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways
Biol Trace Elem Res
Jan 2022
TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy
Neurobiol Dis
Jan 2022
An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn’s disease
Dis Model Mech
Jan 2022
Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
Cell Rep
Jan 2022
Hyaluronan Synthase 3 is Protective After Cardiac Ischemia-Reperfusion by preserving the T cell Response
Matrix Biol
Jan 2022
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
Cell Rep
Jan 2022
6 good reasons to employ our repository Knockout mouse models in your in vivo studies
Eucomm conditional Knockouts
6 min read
-
Aug 2019
A new Nature report by Bristol-Myers Squibb provides new insights into VISTA biology and design of combination therapies
Humanized ICP in immuno-oncology
3 min read
-
Oct 2019
A finely tuned crosstalk between enteric neurons and muscularis macrophages: evidence from a conditional Knockout mouse model developed by genOway
Customized mouse model
3 min read
-
Jan 2020
A Knockin C3-reporter mouse model represents a valuable tool to monitor C3 levels, a biomarker of inflamed versus uninflamed tissues
Customized mouse model
3 min read
-
Apr 2020
Define “humanized”: two mouse models helping produce cancer immunotherapies
Humanized mouse models
4 min read
-
Nov 2020
A novel preclinical and translational humanized CD3ε model to study the efficacy of T-cell engagers
T-cell engager
8 min read
-
Feb 2021
Uncoupling toxicity from therapeutic efficacy: the new challenge of immunotherapies
Assess toxicity with ICP
3 min read
-
Apr 2021
Tumor grafts in preclinical research: Models, models, overall, who is the fittest of them all?
Tumor-graft models
5 min read
-
Aug 2021
A human-specific modifier of cortical connectivity and circuit function
Customized mouse model
3 min read
-
Nov 2021
NOTUM as alternative therapeutic approach to prevent clonal fixation and mutant expansion in patients predisposed to colorectal cancer
Customized mouse model
3 min read
-
Nov 2021
Immunotherapy efficacy assessment and metastases studies: tHIS model is highly permissive to engraftment
Engraftments in BRGSF-HIS
8 min read
-
Nov 2021
Relevant preclinical models to test T-cell engagers: The case of CD28
T-cell engager
5 min read
-
Mar 2022
An alternative approach to immunotherapy: A bispecific agonist
Humanized PD-1 & GITR mouse
4 min read
-
Mar 2022
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model
T-cell engager CD3
3 min read
-
Mar 2022
Targeting tumor-associated myeloid cells: The new grail in immuno-oncology?
Myeloid compartment in immuno-oncology
3 min read
-
Apr 2022
Challenging the predictability of preclinical models for assessment of T-cell engagers
Assess T-cell engager in BRGSF-HIS
5 min read
-
May 2022
Assessing T-cell engagers in vivo: How BRGSF-HIS mice can help
Assess T-cell engager in BRGSF-HIS
6 min read
-
Jun 2022
Functional human myeloid compartment in BRGSF-HIS preclinical model
Myeloid compartment in BRGSF-HIS
4 min read
-
Nov 2022
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension
Humanized HSA/hFcRn mouse
3 min read
-
Nov 2022
Expression of druggable myeloid targets in the BRGSF-HIS preclinical model
Myeloid compartment in BRGSF-HIS
3 min read
-
Mar 2023
Assessing T-cell engagers efficacy in vivo: Versatility of BRGSF-HIS mice
Assess T-cell engager in BRGSF-HIS
3 min read
-
Oct 2023
Targeting myeloid cells in the tumor microenvironment in BRGSF-HIS mice
Myeloid compartment in BRGSF-HIS
7 min read
-
Dec 2023
Homeostasis of monocytes and lung interstitial macrophages is regulated by collagen domain-binding receptor LAIR1 in vivo
Myeloid compartment in BRGSF-HIS
6 min read
-
Jun 2022
Immunocompromised human serum albumin/human neonatal Fc receptor mouse model: A new xenograft model for efficacy studies of immunotherapies
Therapeutic efficacy and pharmacokinetics
8 min read
-
Jan 2022
Predictive in vivo evaluation of immunotherapy efficacy: tHIS is a reliable model
PDX in BRGSF-HIS
6 min read
-
Nov 2021
The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R
Physiological relevancy in preclinical models
4 min read
-
Sep 2021
Deciphering high-dose IL-2 toxicity in reconstituted HIS mice
Immunotherapy in BRGSF-HIS
6 min read
-
Aug 2021
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