Knockin mouse models

A Knockin mouse defines a model in which a gene sequence of interest is altered by one-for-one substitution with a transgene, or by adding gene sequences that are not found within the locus.

The insertion of a transgene is typically done in specific loci. This "targeted" approach causes less disturbances of the transcription-active genetic environment.

Knockin mice are suited to a wide range of application, from the study of regulatory elements such as promotors to the production of therapeutically useful humanized antibodies.

‍

Our Knockin mouse model solutions

Besides conventional Knockins where a gene sequence of interest is added to an endogenous locus, we offer a set of commonly used solutions:

• Quick Knockin™ (Rosa26 and Hprt)
  Full control of your gene expression by targeting the best-studied permissive loci Rosa26 and Hprt.

• Point mutation Knockin mouse
  Affect the function of a given protein (gain or loss of function) by one or more mutated nucleotides

• Reporter mouse
  Monitor genetic events, protein function, localization, and cell trafficking

• Humanized mouse models
  Substitute a mouse gene sequence with the human counterpart

‍