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Applications of the hCD4 mouse model
- Assess the efficacy and safety of CD4-targeting compounds
- Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits
- Analyze the biodistribution of hCD4 targeting constructs and follow the dynamics of CD4+ T cells by live imaging
Features
- Physiological regulation and expression pattern of hCD4
- Unaltered immune cell distribution, and T helper cell activity
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Clients
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