Applications of the hGLP-1R mouse model
Broad range of applications in the fields of metabolism, autoimmunity and neuroscience:
- Assess the efficacy of GLP-1R targeting compounds, such as in the context of treating type 2 diabetes and obesity
- Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential
Features
- Physiological regulation and expression of the humanized GLP-1R
- Fully functional hGLP-1R
- Lack of expression of the murine target gene
- Model is available in a C57BL/6N background
- Fully functional mouse immune system