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Knockout and reporter models
Model Eucomm
>2000 conditional Knockout mouse models for target discovery and confirmation, in vivo compound specificity, MOA, and clinical studies
Related resources and publications
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Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Nat Commun
Jan 2023
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
Cell Rep
Jan 2022
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
PLoS One
Jan 2022
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH
Biochim Biophys Acta Mol Basis Dis
Jan 2022
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Validation data
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Model Eucomm
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