Constitutive KO mouse

Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

Glia

NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

iScience

Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice

Heliyon

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

PLoS One

Jan 2022

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Cell Metab

Jan 2022

Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Commun Biol

Jan 2021

Novel compounds with dual S1P receptor agonist and histamine H 3 receptor antagonist activities act protective in a mouse model of multiple sclerosis

Neuropharmacology

Jan 2021

Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease

Matrix Biol

Jan 2021

MOSPD2 is a therapeutic target for the treatment of CNS inflammation

Clin Exp Immunol

Jan 2020

Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma

Nucleic Acids Res

Jan 2020

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

Nat Commun

Jan 2019

Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF

FEBS Open Bio

Jan 2018

Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases

Mol Ther

Jan 2018

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Elife

Jan 2018

Distinctive Roles for a7 - and a9 -Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Front Cell Neurosci

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

Sci Rep

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Nature

Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing

J Comp Neurol

Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background.

Front Neurosci

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

Proc Natl Acad Sci U S A

Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance toFTY720 but not ST-968 treatments.

Neuropharmacology

Infiltration of CCR2+Ly6Chigh Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis

J Immunol

Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis

J Am Coll Cardiol

Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival

PLoS One

Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system.

J Appl Physiol

Impairment of PARK14-dependent Ca2 þ signalling is a novel determinant of Parkinson’s disease.

Nat Commun

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma Raymond G.

Nature

Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock–induced oxidation

FASEB J

CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice

Sci Rep

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

Nature

Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin.

Int J Obes (Lond)

Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-induced Expression of RANKL.

Endocrinology

The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

Am J Physiol Regul Integr Comp Physiol

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Nat Commun

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

Free Radic Biol Med

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

PLoS One

Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner

Proc Natl Acad Sci U S A

Deletion of the Distal Tnfsf11 RL-D2 Enhancer that Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice.

J Bone Miner Res

Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation

Mol Genet Genomic Med

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.

Chem Senses

Brain Serotonin Signaling Does Not Determine Sexual Preference in Male Mice

PLoS One

PILRα negatively regulates mouse inflammatory arthritis

J Immunol

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.

ACS Chem Neurosci

Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin

J Appl Physiol (1985)

Salty Taste Deficits in CALHM1 Knockout Mice

Chem Senses

Glycogen storage disease type III: A novel Agl knockout mouse model

Biochim Biophys Acta

DRAGO (KIAA0247), a New DNA Damage-Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosupprossor.

J Natl Cancer Inst

Effect of light on global gene expression in the neuroglobin-deficient mouse retina

Biomedical Reports

Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low fat contents

Biochimie

Brain serotonin determines maternal behavior and offspring survival.

Genes Brain Behav

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse

Mol Vis

XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation.

J Biol Chem

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice

PLoS One

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

J Vis Exp

Helicase-like transcription factor (hltf) regulates g2/m transition, wt1/gata4/hif-1a cardiac transcription networks, and collagen biogenesis.

PLoS One

Differential modulation of EAE by α9-and β2-nicotinic acetylcholine receptors

Immunol Cell Biol

CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons.

J Cell Sci

Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

Circulation

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

Diabetologia

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.

Exp Neurol

Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain

PLoS One

Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease.

J Lipid Res

Neuronal Expression of Soluble Adenylyl Cyclase in the Mammalian Brain.

Brain Res

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

J Biol Chem

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

PLoS One

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.

Nature

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

Mol Cell

Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism

PLoS One

Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity

J Neurochem

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Nature (Letter)

The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.

EMBO J

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility.

Mol Endocrinol

Role of the Polarity Protein Scribble for Podocyte Differentiation and Maintenance

PLoS One

Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase

Biochem Biophys Res Commun

Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo

ETSM

Mammary gland development is delayed in mice deficient for aminopeptidase N

Transgenic Res

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency

Proc Natl Acad Sci U S A

Flower-deficient mice have reduced susceptibility to skin papilloma formation

Dis Model Mech

Disruption of the histidine triad nucleotide‐binding hint2 gene in mice affects glycemic control and mitochondrial function

Hepatology

Circadian Behaviour in Neuroglobin Deficient Mice

PLoS One

Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.

Stem Cells

Cellular ageing, increased mortality and FTLD‐TDP‐associated neuropathology in progranulin knockout mice

J Pathol

Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.

Proc Natl Acad Sci U S A

Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/⁺Gr-1⁺ myeloid cells--brief report

Arterioscler Thromb Vasc Biol

Neuroglobin-Deficiency Exacerbates Hif1A and c-FOS Response, but Does Not Affect Neuronal Survival during Severe Hypoxia In Vivo

PLoS One

Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

PLoS One

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

Proc Natl Acad Sci U S A

Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)

J Neurosci

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

Proc Natl Acad Sci U S A

Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival

J Biol Chem

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Proc Natl Acad Sci U S A

CCN2 is not required for skin development

J Cell Comm Signal

A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver

Biochimie

Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.

J Biol Chem

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana.

PLoS Pathog

Trace amines depress D2-autoreceptor-mediated responses on midbrain dopaminergic cells

Br J Pharmacol

The Role of Endogenous Serotonin in Methamphetamine-Induced Neurotoxicity to Dopamine Nerve Endings of the Striatum

J Neurochem