Humanized PD-1/PD-L1 mouse and cell line
Front Immunol
PLoS One
Immunology
A quick Knockin cell line has a transgene inserted into permissive loci (e.g., Rosa26). The transgene overexpression is constitutively or inducibly.
A Quick Knockin cell line defines a model in which a transgene is inserted in a permissive locus, also known as neutral locus or safe harbor, such as Rosa26. The transgene can be constitutively or inducibly overexpressed.
Targeting those loci enables full control of the copy number and avoids transgene silencing or deregulation of neighbouring genes.
For academic research:
For bio-pharmaceutical research & development:
Humanized PD-1/PD-L1 mouse and cell line
Front Immunol
PLoS One
Immunology
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