Target

Gene symbol :  
Btk
NCBI gene ID :  
12229
Gene full name :  
Bruton tyrosine kinase
Synonym :  
Xid, Bruton

Protein function

Protein name :  
BTK
Non-receptor tyrosine kinase critical for B-cell development and receptor signaling.

Expected phenotype

Blocked B-cell maturation, immunodeficiency

Human disease relevance

Responsible for X-linked agammaglobulinemia (XLA)

Model applications

Immunodeficiency models, B-cell receptor signaling

Keywords:

B-cell, XLA, Immunodeficiency, BTK inhibitors

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • WoldWide delivery by professional breeders

Btk

conditional Knockout Mouse

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