Scientifique articles of research breakthroughs | genOway

Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model

J Clin Invest

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639

Scientific articles

Increased Cholineargic Response in α-Synuclein Transgenic Mice (h-aα-synL62).

ACS Chem Neurosci

Humanization of the Blood–Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus — Lessons from Three Unsuccessful Approaches

Eur J Microbiol Immunol

Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.

Transplantation

GIMAP6 is required for T cell maintenance and efficient autophagy in mice

PLoS One

Development of full sweet, umami, and bitter taste responsiveness requires Regulatorof G protein Signaling-21 (RGS21).

Chem Senses

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

Nat Commun

Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.

Sci Rep

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Cancer Cell

Chromosome structural anomalies due to aberrant spindle forces exerted at gene editing sites in meiosis

J Biol Chem

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.

Cell Metab

Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control

Eur Neuropsychopharmacol

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Elife

Alpha-Synuclein transgenic mice, h- -SynL62, display -Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson’s disease

Behavioural Brain Research

Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface.

PLoS One

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.

PLoS One

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

Nat Commun

Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments

PLoS One

Paired Siglec receptors generate opposite inflammatory responses to a human‐specific pathogen.

EMBO J

Myeloid ATG16L1 Facilitates Host–Bacteria Interactions in Maintaining Intestinal Homeostasis

J Immunol

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease

Proc Natl Acad Sci U S A

Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression

Matrix Biol

Distinctive Roles for a7 - and a9 -Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Front Cell Neurosci

Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

Sci Adv

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

J Exp Med

An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes

JCI Insight

Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice

Eur J Immunol

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

Sci Rep

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Nature

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

Proc Natl Acad Sci U S A

The impact of VDR expression and regulation in vivo

J Steroid Biochem Mol Biol

Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction

Am J Pathol

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.

Hippocampus

Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries.

Aging Cell

Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing

J Comp Neurol

Molecular and functional characterization of the endothelial ATP-sensitive potassium channel.

J Biol Chem

Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.

Psychoneuroendocrinology

Generation and characterization of mice for conditional inactivation of Zeb1

Genesis

Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background.

Front Neurosci

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

Nature

Distinct regulatory effects of myeloid cell and endothelial cell Nox2 on blood pressure

Circulation

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A

Arterioscler Thromb Vasc Biol

Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors

Gene Expr Patterns

CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing

Sci Rep.

Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases

Sci Rep.

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

Proc Natl Acad Sci U S A

Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance toFTY720 but not ST-968 treatments.

Neuropharmacology

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

J Clin Invest

Infiltration of CCR2+Ly6Chigh Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis

J Immunol

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.

J Exp Med

Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis

J Am Coll Cardiol

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Cell Metab

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification

Artherosclerosis

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

Nucleic Acids Res

The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.

Cell Rep

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

Brain

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop.

Circ Res

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

Cell Death Differ

Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.

J Biol Chem

Pyk2 is Essential for Astrocytes Mobility Following Brain Lesion

Glia

PI3-kinase mutation linked to insulin and growth factor resistance in vivo

J Clin Invest

Nuc-ErbB3 Regulates H3K27me3 Levels and HMT Activity to Establish Epigenetic Repression during Peripheral Myelination

Glia

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

Nat Med

NLRP3 recruitment by NLRC4 during Salmonella infection

J Exp Med

Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival

PLoS One

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

Cell Rep

Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments

Life Sci Space Res (Amst)

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B

JCI Insight

Knock-in of the Recurrent R368X Mutation of PRKAR1A that Represses cAMP-Dependent Protein Kinase A Activation: A Model of Type 1 Acrodysostosis.

J Bone Miner Res

Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system.

J Appl Physiol

Impairment of PARK14-dependent Ca2 þ signalling is a novel determinant of Parkinson’s disease.

Nat Commun

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma Raymond G.

Nature

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

Nat Commun

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling andshaping lymphocyte dynamics.

Nat Commun

Generation of a double transgenic humanised neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs

J Control Release

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

Cell Rep

Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations

Cell Death Discovery

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Arterioscler Thromb Vasc Biol

Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock–induced oxidation

FASEB J

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β cell are associated with glucose intolerance in humans and mice

Am J Physiol Endocrinol Metab

CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice

Sci Rep

C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.

PLoS One

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

Nature

An antibody biosensor establishes the activation of the M1 muscarinic acetylcholine receptor during learning and memory

J Biol Chem

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation

Sci Rep

Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins

Sci Rep.

Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin.

Int J Obes (Lond)

Transgenic Overexpression of Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification.

J Am Heart Assoc

Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model

Diabetes

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.

Elife

Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy

PloS Genetics

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

Proc Natl Acad Sci U S A

Development of Congenital Stromal Corneal Dystrophy Is Dependent on Export and Extracellular Deposition of Truncated Decorin

Invest Ophthalmol Vis Sci

Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.

Circulation

Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-induced Expression of RANKL.

Endocrinology

The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

Am J Physiol Regul Integr Comp Physiol

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

J Biol Chem

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.

Brain Res

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.

J Clin Invest

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/b-Catenin Signaling

Dev Cell

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Nat Commun

MALT1 Protease Plays a Dual Role in the Allergic Response by Acting in Both Mast Cells and Endothelial Cells

J Immunol

Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration

Dev Cell

Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation

Acta Neuropathol Commun

HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis

Cell Rep

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

Sci Signal

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production

Sci Adv

Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Q pool

Sci Adv

Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

Nat Metab

Estrogen Receptor a Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy

JACC Basic Transl Sci

ERα-36 regulates progesterone receptor activity in breast cancer

Breast Cancer Res

Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1+/− Mice

Int J Mol Sci

Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease

Cell Death Dis

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells

Immunity

Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma

Nucleic Acids Res

Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

Nat Neurosci

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Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury

J Neurosci

A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

Epilepsia

4PBA Restores Signalling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with PAH

Am J Respir Cell Mol Biol

Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in

Sci Rep.

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The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

J Immunother Cancer

Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis.

Commun Biol

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.

Acta Neuropathol Commun

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopaminedependent behaviors

J Clin Invest

Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice

Sci Rep

4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

Nat Metab

VISTA is an acidic pH-selective ligand for PSGL-1

Nature

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Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF

Cancer Immunol Res

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks

Proc Natl Acad Sci U S A

The VEGF-A exon 8 splicing-sensitive fluorescent reporter mouse is a novel tool to assess the effects of splicing regulatory compounds in vivo

RNA Biol

The mouse intron-nested gene, Israa, is expressed in the lymphoid organs and involved in T-cell activation and signaling

Mol Immunol

The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

Nature

SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.

Proc Natl Acad Sci U S A

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Cell

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.

Nat Immunol

Sertoli cell-specific coxsackievirus and adenovirus receptor knockout regulates cell adhesion and gene transcription via β-catenin inactivation and Cdc42 activation

FASEB J

Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control

Proc Natl Acad Sci U S A

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.

Purinergic Signal

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

Nat Commun

Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice

Mol Neurobiol

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA

Cell Rep

Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles

EMBO J

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Nat Commun

Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory

J Neurosci

Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.

Histochem Cell Biol

Molybdenum cofactor deficiency type B knock-in mouse models carrying patient-identical mutations and their rescue by singular AAV injections

Hum Genet

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

J Clin Invest

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.

Cell Rep

Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells

DNA Repair

Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.

Nitric Oxide

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Cell Metab

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