Scientifique articles of research breakthroughs | genOway

Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits

Brain

February 5, 2025

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Scientific articles

Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits

Brain

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice

Alzheimers Res Ther

EBP1 potentiates amyloid β pathology by regulating γ-secretase

Nat Aging

NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control

Cancer Immunol Res

Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling

Nat Commun

GalNT2-mediated O-glycosylation affects pancreas development and function in mice

Sci Rep

NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Biomaterials

Neuromedin U Neurons in the Edinger-Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response

Neurochem Res

Efficient generation of human immune system rats using human CD34+ cells

Stem Cell Reports

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Theranostics

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Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993

Eur J Nucl Med Mol Imaging

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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

Geroscience

Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

Invest Ophthalmol Vis Sci

Missense mutation (C667F) in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization

Dis Model Mech

An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

Sci Transl Med

A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia

Sci Rep

Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution

JCI Insight

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression

Mol Cancer Ther

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Nat Neurosci

HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors

Mol Cancer Ther

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INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment

Mol Cancer Ther

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Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells

J Am Soc Nephrol

Fitusiran reduces bleeding in Factor X-deficient mice

Blood

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Nat Commun

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Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia

Neurobiol Dis

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas

Hum Mol Genet

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Nat Cardiovasc Res

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

Nat Commun

Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Front Immunol

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Nat Commun

An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies

Front Immunol

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Front Immunol

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function

Cell Death Dis

Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

JBMRplus

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Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9

Hear Res

Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of HDL and LDL in opposite ways

Cardiovasc Res

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Front Immunol

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Detecting Central Auditory Processing Disorders in Awake Mice

Brain Science

Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

Cell Mol Life Sci

Biodistribution and function of coupled polymer-DNA origami nanostructures

Sci Rep

Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice

Heliyon

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Front Immunol

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Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer

Cancer Cell

Cathepsin D overexpression in the nervous system rescues lethality and Ab42 accumulation of cathepsin D systemic knockout in vivo

Acta Pharm Sin B

Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia

Autophagy

Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells

Open Biol

The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma

Cancer Res

Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment

Proc Natl Acad Sci U S A

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

EMBO Rep

SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties

Immunohorizons

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

PLoS One

Brain-derived Estrogen: A Critical Player in Maintaining Cognitive Health of Aged Female Rats, Possibly Involving GPR30

Neurobiol Aging

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion

J Lipid Res

Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion

JCI Insight

CCX559 is a potent orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

PLoS One

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Multilineage commitment of Sca-1+ cells in reshaping vein grafts

Theranostics

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Nat Commun

Neoadjuvant immunotherapy for melanoma is now ready for clinical practice

Nat Med

Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice

PLoS One

Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning

Int J Mol Sci

NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

iScience

Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes

Life Sci Alliance

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Nat Commun

Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice

PLoS One

Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events

Kidney Int

NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer

Cancers (Basel)

Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice

Cell Rep

Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

Cell Rep Med

A gain-of-function filamin A mutation in mouse platelets induces thrombus instability

J Thromb Haemost

Taurine depletion impairs cardiac function and affects tolerance to hypoxia and high temperatures in brook char (Salvelinus fontinalis)

J Exp Biol

Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response

Nat Cardiovasc Res

Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity

PLoS One

Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

Glia

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

FASEB J

An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn’s disease

Dis Model Mech

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Cell Metab

Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features

Am J Respir Cell Mol Biol

The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Pancreatology

An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Acta Biomater

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KCC2 drives chloride microdomain formation in dendritic blebbing

Cell Rep

Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH

Biochim Biophys Acta Mol Basis Dis

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Nat Commun

Hyaluronan Synthase 3 is Protective After Cardiac Ischemia-Reperfusion by preserving the T cell Response

Matrix Biol

Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells

Front Immunol

Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection

Sci Rep

IgG against the membrane-proximal portion of the desmoglein 3 ectodomain induces loss of keratinocyte adhesion, a hallmark in pemphigus vulgaris

J Invest Dermatol

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells

J Allergy Clin Immunol

An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

Acta Neuropathol

Enhanced half-life and antitumor activity of Interleukin-15 through genetic fusion of a serum albumin-specific protein binder

Int J Pharmac

ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways

Biol Trace Elem Res

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

J Immunother Cancer

Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis

Prog Neurobiol

Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading

Int J Mol Sci

Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice

Nat Commun

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Nat Metab

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Breast Cancer Res

Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity

iScience

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