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Knockout and reporter models

Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.

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Knockout models

Knockout models, a cornerstone in biomedical research, involve the targeted inactivation of specific genes to understand their function. By "knocking out" a gene, you can observe the resulting phenotype changes, shedding light on the gene's role in health and disease.

Platforms like the European Conditional Mouse Mutagenesis Program contribute significantly, providing a standardized approach to generating and studying Knockout mice. These models are instrumental in deciphering gene functions, offering crucial insights into molecular pathways and potential therapeutic targets.

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Reporter models

Reporter models are genetically modified with reporter genes, like fluorescent proteins, to enable real-time visualization of specific biological processes.

They serve as invaluable tools for researchers, providing dynamic insights into disease progression, treatment responses, and the effects of genetic modifications.

By observing the behavior of reporter genes in living animals, scientists gain a deeper understanding of complex biological mechanisms, making these models indispensable in advancing biomedical research.

FGF21

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Fibroblast growth factor 21

Synonyms:
Fibroblast growth factor 21
Gene ID (NCBI):
56636
Protein function:
Regulates glucose and lipid metabolism, especially under fasting conditions.
Applications:  
Metabolic and diabetes research.

Tlr9

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Toll-like receptor 9

Synonyms:
Toll-like receptor 9
Gene ID (NCBI):
24088
Protein function:
Plays a role in pathogen recognition and activation of innate immunity.
Applications:  
Autoimmunity and pathogen recognition research.

Klk5

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Kallikrein-related peptidase 5

Synonyms:
Kallikrein-related peptidase 5
Gene ID (NCBI):
234779
Protein function:
Involved in skin desquamation and barrier function.
Applications:  
Skin barrier and dermatology research.

mir142

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MicroRNA 142

Synonyms:
MicroRNA 142
Gene ID (NCBI):
387059
Protein function:
Regulates gene expression, especially in immune cells.
Applications:  
Gene regulation and immune research.

Usp30

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Ubiquitin specific peptidase 30

Synonyms:
Ubiquitin specific peptidase 30
Gene ID (NCBI):
333786
Protein function:
Involved in mitochondrial quality control via ubiquitination pathways.
Applications:  
Mitochondrial research and neurodegeneration models.

IL-17a/IL-17f

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Interleukin 17A/F

Synonyms:
Interleukin-17A/F
Gene ID (NCBI):
257642
Protein function:
Involved in immune response, particularly in promoting inflammation.
Applications:  
Autoimmunity and inflammation research.

Rbm24

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RNA binding motif protein 24

Synonyms:
RNA binding motif protein 24
Gene ID (NCBI):
237911
Protein function:
Plays a role in muscle cell differentiation and maintenance.
Applications:  
Muscle differentiation and development research.

IL17f

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Interleukin 17F

Synonyms:
Interleukin-17F
Gene ID (NCBI):
257630
Protein function:
Involved in immune response, particularly in inflammation and autoimmune diseases.
Applications:  
Inflammatory and autoimmune disease research.

cmtm4

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CKLF-like MARVEL transmembrane domain containing 4

Synonyms:
CKLF-like MARVEL transmembrane domain containing 4
Gene ID (NCBI):
240640
Protein function:
Involved in immune response and cell membrane stability.
Applications:  
Cancer and immune signaling research.

Cmtm6

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CKLF-like MARVEL transmembrane domain containing 6

Synonyms:
CKLF-like MARVEL transmembrane domain containing 6
Gene ID (NCBI):
227399
Protein function:
Modulates PD-L1 expression in immune cells.
Applications:  
Immune checkpoint and cancer research.
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Knockout and reporter models

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genO-Btk rat

genO-Btk Knockout rat to study B-cell malignancies, aberrant B-cell responses, Btk inhibitors for treatments of hematologic cancers or autoimmune diseases.

BTK
Immunodeficient
KO-Rep-Mix

genO-GFP rat

The genO-GFP rat is suitable for organ & tissue transplantations and used in many biomedical fields (development, toxicology, orthotopic transplantation).

GFP
KO-Rep-Mix

genO‑HSA/hFcRn-RAG1KO

This upgraded, immunocompromised RAG1-/- version of our genO-HSA/hFcRn mouse model allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

HSA
PK/PD
Fc receptor
KO-Rep-Mix

IL-4-IRES-eGFP

The reliable monitoring and sorting of IL-4-secreting cells allows you to efficiently delineate the immune response polarization toward the Th2 pathway.

IL-4
KO-Rep-Mix

KO repository

>2000 conditional Knockout mouse models for target discovery and  confirmation, in vivo compound specificity, MOA, and clinical studies

Eucomm
KO-Rep-Mix

Discover our customized models

Learn  more

Related resources and publications

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Evolutionary fingerprints of epithelial-to-mesenchymal transition

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NK2R control of energy expenditure and feeding to treat metabolic diseases

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PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

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Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

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The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma

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Multilineage commitment of Sca-1+ cells in reshaping vein grafts

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Apelin controls emotional behavior in age- and metabolic state-dependent manner

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Other categories

Conditional Knockout mice

Our off-the-shelf conditional Knockout models are well-established, validated and widely used mouse lines.
Learn more

Immunodeficient rodents

Explore our immunodeficient models, featuring cutting-edge strains like BRGSF mouse and SDRG rat.
Learn more

Humanized mice (HIS/human immune system)

Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.
Learn more

Humanized mice (target-specific)

Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.
Learn more

Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.
Learn more