Scientifique articles of research breakthroughs | genOway

NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

November 13, 2024

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Scientific articles

Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors

Cell Stem Cell

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

Diabetologia

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

Science

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Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.

Acta Neuropathol Commun

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

Cell

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The VEGF-A exon 8 splicing-sensitive fluorescent reporter mouse is a novel tool to assess the effects of splicing regulatory compounds in vivo

RNA Biol

Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control

Proc Natl Acad Sci U S A

Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF

Cancer Immunol Res

Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice.

Leukemia

Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis.

Commun Biol

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology

Sci Signal

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.

Cell Stem Cell

The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

Nature

4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

Nat Metab

A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis

Cell Rep

Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles

EMBO J

Helicase-like transcription factor (Hltf) gene-deletion promotes oxidative phosphorylation (OXPHOS) in colorectal tumors of AOM/DSS-treated mice

PLoS One

Identification of an ATP-sensitive potassium channel in mitochondria.

Nature

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.

Nat Immunol

Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation

Neurobiol Dis

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Cell

Identification of a Core Amino Acid Motif within the a Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

Cell Rep

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.

Purinergic Signal

SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.

Proc Natl Acad Sci U S A

The mouse intron-nested gene, Israa, is expressed in the lymphoid organs and involved in T-cell activation and signaling

Mol Immunol

Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic Thy1-Gfp Rat Model

JAMA Facial Plast Surg

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival

Sci Signal

Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.

Histochem Cell Biol

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopaminedependent behaviors

J Clin Invest

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.

Cell Rep

Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells

DNA Repair

Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice

Mol Neurobiol

A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

Nat Commun

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

Nat Chem Biol

The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

J Immunother Cancer

An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials

Immunity

Deubiquitinase USP10 regulates Notch signaling in the endothelium

Science

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA

Cell Rep

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks

Proc Natl Acad Sci U S A

Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4–induced M2 macrophage polarization

FASEB J

Sertoli cell-specific coxsackievirus and adenovirus receptor knockout regulates cell adhesion and gene transcription via β-catenin inactivation and Cdc42 activation

FASEB J

Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in

Sci Rep.

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Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice

Sci Rep

Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.

Nitric Oxide

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

Nat Commun

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models

Sci Adv

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

J Clin Invest

Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity

J Physiol Biochem

Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory

J Neurosci

ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin

Cell Rep

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Cell Metab

Molybdenum cofactor deficiency type B knock-in mouse models carrying patient-identical mutations and their rescue by singular AAV injections

Hum Genet

Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels

Transl Psychiatry

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Nat Commun

Attenuation in Nicotinic Acetylcholine Receptor 9 and 10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis

Biomolecules

Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF‐A2 humanized mice resemble those in human samples

J Leukoc Biol

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

Elife

Increased Cholineargic Response in α-Synuclein Transgenic Mice (h-aα-synL62).

ACS Chem Neurosci

Constitutive serotonin transporter reduction resembles maternal separation with regard to stress-related gene expression

ACS Chem Neurosci

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Elife

Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.

Cell Rep

5-HT3 receptor signaling in serotonin transporter knockout rats: a female sex specific animal model of visceral hypersensitivity.

Am J Physiol Gastrointest Liver Physiol

Humanization of the Blood–Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus — Lessons from Three Unsuccessful Approaches

Eur J Microbiol Immunol

Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism

Mucosal Immunol

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations

EMBO Rep

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice.

Exp Mol Med

Murine transcription factor Math6 is a regulator of placenta development

Sci Rep

REST overexpression in mice causes deficits in spontaneous locomotion

Sci Rep

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Proc Natl Acad Sci U S A

βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload

J Clin Invest

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

Proc Natl Acad Sci U S A

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma

Pigment Cell Melanoma Res

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Cancer Cell

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

Nat Commun

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

Biochem Biophys Res Commun

GIMAP6 is required for T cell maintenance and efficient autophagy in mice

PLoS One

Chromosome structural anomalies due to aberrant spindle forces exerted at gene editing sites in meiosis

J Biol Chem

Histological and behavioural phenotypes of a novel mutated APP knock-in mouse

J Alzheimers Dis

Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH

Sci Signal

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.

Sci Signal

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

Cell Physiol Biochem

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation

FASEB J

Understanding tendons: lessons from transgenic mouse models

Stem Cells Dev

Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface.

PLoS One

R-Ras1 and R-Ras2 are essential for oligodendrocyte differentiation and survival for correctmyelination in the central nervous system.

J Neurosci

Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases

Mol Ther

Neuronatin regulates pancreatic b cell insulin content and secretion

J Clin Invest

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.

Cell Metab

Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.

Sci Rep

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

J Neuroinflammation

Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.

Transplantation

Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF

FEBS Open Bio

Development of full sweet, umami, and bitter taste responsiveness requires Regulatorof G protein Signaling-21 (RGS21).

Chem Senses

Loss of neuroglobin-expression alters Cdkn1a/Cdk6-expression resulting in increased proliferation of neural stem cells.

Stem Cells Dev

Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.

J Biol Chem

A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy

PLoS One

Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control

Eur Neuropsychopharmacol

Alpha-Synuclein transgenic mice, h- -SynL62, display -Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson’s disease

Behavioural Brain Research

Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

Invest Ophthalmol Vis Sci

Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.

Psychoneuroendocrinology

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