Our cases studies
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Homeostasis of monocytes and lung interstitial macrophages is regulated by collagen domain-binding receptor LAIR1 in vivo
Myeloid compartment in BRGSF-HIS
6 min read
-
Jun 2022
Mouse
Immuno-Oncology
HIS
Myeloid compartment
BRGSF
2022
New insights to manage painful neuroma: Study of a nerve graft in rats
Rat models
7 min read
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Mar 2022
Rats
2022
Immunocompromised human serum albumin/human neonatal Fc receptor mouse model: A new xenograft model for efficacy studies of immunotherapies
Therapeutic efficacy and pharmacokinetics
8 min read
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Jan 2022
Mouse
Immuno-Oncology
HSA
Immunotherapy
Humanized targets
2022
Predictive in vivo evaluation of immunotherapy efficacy: tHIS is a reliable model
PDX in BRGSF-HIS
6 min read
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Nov 2021
Mouse
Immuno-Oncology
HIS
BRGSF
2021
The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R
Physiological relevancy in preclinical models
4 min read
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Sep 2021
Mouse
Immuno-Oncology
GLP-1R
Humanized targets
Reporter
2021
Deciphering high-dose IL-2 toxicity in reconstituted HIS mice
Immunotherapy in BRGSF-HIS
6 min read
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Aug 2021
Mouse
Immuno-Oncology
HIS
Immunotherapy
BRGSF
2021
Uncoupling toxicity from therapeutic efficacy: a case study on ATOR-1015
Bispecific antibodies
5 min read
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Apr 2021
Mouse
Immuno-Oncology
Immune checkpoint
OX40
Humanized targets
2021
Uncoupling efficacy from toxicity: a case study on MEDI5752
Bispecific antibodies
5 min read
-
Apr 2021
Mouse
Immuno-Oncology
Immune checkpoint
Humanized targets
CTLA-4
2021
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