Scientifique articles of research breakthroughs | genOway

NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

November 13, 2024

Articles with our models

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Scientific articles

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

Proc Natl Acad Sci U S A

Effect of light on global gene expression in the neuroglobin-deficient mouse retina

Biomedical Reports

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

J Clin Invest

Clic4, a novel protein that sensitizes β-cells to apoptosis.

Mol Metab

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo

Blood

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/b-Catenin Signaling

Dev Cell

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.

Chem Senses

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats.

Eur J Pharmacol

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

J Bone Miner Res

Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model

Diabetes

Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury

BMC Pharmacology and Toxicology

Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells

Mol Cell Biol

Ins1 Cre knock-in mice for beta cell-specific gene recombination

Diabetologia

The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

Am J Physiol Regul Integr Comp Physiol

A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.

Am J Respir Cell Mol Biol

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse

Mol Vis

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes

J Neurosci

Glycogen storage disease type III: A novel Agl knockout mouse model

Biochim Biophys Acta

Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula

J Neurosci

NTPDase2 and Purinergic Signaling Control Progenitor Cell Proliferation in Neurogenic Niches of the Adult Mouse Brain

Stem Cells

The toxic effect of R350P mutant desmin in striated muscle of man and mouse

Acta Neuropathol

ALKBH4 Depletion in Mice Leads to Spermatogenic Defects

PLoS One

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis

J Mol Med

Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin.

Int J Obes (Lond)

The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

Cell Metab

Endothelial C-type natriuretic peptide maintains vascular homeostasis.

J Clin Invest

Brain serotonin determines maternal behavior and offspring survival.

Genes Brain Behav

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.

ACS Chem Neurosci

Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice

Lab Invest

Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation.

Cell Rep

Phenotypic Characterization of miR-92a2/2 Mice Reveals an Important Function of miR-92a in Skeletal Development

PLoS One

Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases

Genome Res.

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

Mucosal Immunol

Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury.

Cardiovasc Res

A conditional knockout mouse model reveals endothelial cells as the predominant and possibly exclusive source of plasma factor VIII

Blood

Salty Taste Deficits in CALHM1 Knockout Mice

Chem Senses

Cerebral Cortex Hyperthyroidism of Newborn Mct8- Deficient Mice Transiently Suppressed by Lat2 Inactivation

PLoS One

PILRα negatively regulates mouse inflammatory arthritis

J Immunol

DRAGO (KIAA0247), a New DNA Damage-Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosupprossor.

J Natl Cancer Inst

The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo

Transgenic Res

RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

J Immunol

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.

Exp Neurol

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

J Vis Exp

The regulatory T cells induction by Epicutaneous immunotherapy is sustained and mediates long term protection from eosinophilic disorders in peanut sensitized mice

Clin Exp Allergy

Serotonin Reuptake Transporter Deficiency Modulates the Acute Thermoregulatory and Locomotor Activity Response to 3,4-({+/-})-Methylenedioxymethamphetamine, and Attenuates Depletions in Serotonin Levels in SERT-KO Rats

Toxicol Sci

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.

Science

CCN2 expression by fibroblasts is not required for cutaneous tissue repair.

Wound Repair Regen

Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin

J Appl Physiol (1985)

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

Cell Death Differ

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

J Clin Invest

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice

PLoS One

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis.

Development

Relevance of Nck-CD3{varepsilon} Interaction for T Cell Activation In Vivo.

J Immunol

AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: Implications for myocardial differentiation and regional identity

Dev Biol

Changes in neural network homeostasis trigger neuropsychiatric symptoms.

J Clin Invest

IG20/MADD Plays a Critical Role in Glucose-Induced Insulin Secretion

Diabetes

Helicase-like transcription factor (hltf) regulates g2/m transition, wt1/gata4/hif-1a cardiac transcription networks, and collagen biogenesis.

PLoS One

Paneth cells as a siteoforigin for intestinal inflammation

Nature

Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low fat contents

Biochimie

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

PLoS One

Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice

Am J Hum Genet

Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity

Fertil Steril

Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model

Cellular Signalling

Inhibition of MicroRNA-92a Protects Against Ischemia-Reperfusion Injury in a Large Animal Model.

Circulation

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson’s disease triggered by mitochondrial stress

Neuropharmacology

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

J Biol Chem

Visualising Androgen Receptor Activity in Male and Female Mice

PLoS One

Impact of inhibitory constraint of interneurons on neuronal excitability

J Neurophysiol

Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.

Exp Neurol

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

Blood

Role of the ectonucleotidase NTPDase2 in taste bud function

Proc Natl Acad Sci U S A

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

Diabetologia

Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism.

J Mol Cell Cardiol

The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells.

EMBO J

Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: Glycogen overproduction induces apoptosis in male germ cells.

J Cell Biochem

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs

Nat Med

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.

Cell Mol Life Sci

Neuronal Expression of Soluble Adenylyl Cyclase in the Mammalian Brain.

Brain Res

Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain

PLoS One

Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.

Hum Mol Genet

P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.

Res Vet Sci

Deletion of mouse Alkbh7 leads to obesity.

J Mol Cell Biol

Visceral hypersensitivity in female but not in male serotonin transporter knockout rats.

Neurogastroenterol Motil

Downregulation of FOXP1 is required during germinal center B-cell function.

Blood

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

Nat Commun

Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation

Blood

Characterization of Acid sphingomyelinase activity in human cerebrospinal fluid.

PLoS One

Disruption of the histidine triad nucleotide‐binding hint2 gene in mice affects glycemic control and mitochondrial function

Hepatology

Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease.

J Lipid Res

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model

Blood

Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

Circulation

Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions.

Cytoskeleton

Mammary gland development is delayed in mice deficient for aminopeptidase N

Transgenic Res

The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain

PloS Genetics

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.

Nature

CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons.

J Cell Sci

Differential modulation of EAE by α9-and β2-nicotinic acetylcholine receptors

Immunol Cell Biol

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

BioMed Research International

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.

FASEB J

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development.

J Immunol

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