A humanized mouse defines a Knockin model in which a mouse gene is replaced by either a human gene, genomic sequence or regulatory element.

This substitution can target parts of the gene, and subsequently specific domains of the protein, as well as certain mouse regulatory elements such as the promoter.

Typical applications are:

  • Phenocopy human diseases for drug development and safety studies
  • Provides a model to study efficacy when endogenous mouse target shows low affinity to xenobiotics or biologics
  • Create a mouse model tolerant of human antigen for antibody or antibody drug conjugate (ADC) testing
  • Human cytokine expression to improve human immune system engraftment
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Discover also our mouse model with human immune system - BRGSF-HIS

BRGSF-HIS features

The BRGSF-HIS mouse model possesses all of the major human hematopoietic cell subsets, such as B cells, T cells (including CD4+ Treg cells), NK cells, and the myeloid compartment, including dendritic cells (DCs), plasmacytoid cells (pDCs), and monocytes/macrophages.

  • Highly permissive to human xenograft, including primary or established tumor cells (CDX or PDXs) by virtue of the SIRPαNOD allele expression
  • Lifespan after humanization similar to that of the wild-type mouse ⇨ supports long-term engraftment studies
  • Robustness to traveling (stable immune system)
  • Suitable to assess the effects of radiation treatment in vivo due to the absence of the SCID mutation on a BALB/c background
  • A complete, functional complement system makes this a powerful tool for complement-dependent cytotoxicity (CDC) studies
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Humanized mouse models

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