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The BRGSF-HIS mouse possesses the most functional reconstituted human immune system currently available on the market. Indeed, this mouse, based on the cutting edge BRGSF model, offers new opportunities to address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.
Applications of the BRGSF-HIS mouse model
The BRGSF-HIS mouse model can address a broad spectrum of therapeutic areas and applications, including bispecific antibodies, immuno-oncology, infectiology, vaccines, drug screening, and personalized medicine.
- Application in tumor biology:
- Assessment of myeloid and lymphoid human cells recruitment and activation profile into the tumor microenvironment (TME) shaped by tumor cell type and tumor burden
- Application in efficacy assessment of:
- T-cell engagers
- Myeloid-targeted therapies aiming at reprogramming the TME
- Depleting agents working via ADCP and ADCC
- γδ T-cell expanders, as the model has shown to develop different subsets of γδ T cells
- Application in safety assessment of:
- Anti-CD3 OKT3 antibody which targets the lymphoid and/or myeloid compartments, demonstrating the development of the hallmark features of cytokine release syndrome, as well as CRS-associated features induced by T-cell or myeloid targeting agents. The OKT3-induced CRS features could be alleviated by Infliximab
- Anti-VISTA pH-selective antibody, showing the safety of SNS-101 therapeutic antibody
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