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Applications of the genO‑hFcγR mouse model
Broad range of applications in the fields of immuno-oncology, infectious diseases, inflammation and autoimmunity:
- Assess the Fc-mediated effector function of biologics:
- Evaluation of B-cell depletion following treatment with anti-CD20 antibodies
- Testing the protective role of antibodies in the context of infection, such as influenza
- Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
- Rank Fc-engineered antibodies with enhanced or reduced binding to FcγR
- Gain insight into the mechanism of action (MOA) of biologics
Features
- Fully immunocompetent model
- genO‑hFcγR mice have a human-like expression pattern
- No expression of murine FcγR
- Functional receptors enabling assessment of Fc-mediated effector functions
Clients
