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hFcγR
Humanized mice (target-specific)

Preclinical humanized FcγR Mouse Model

Preclinical humanized Fc-gamma receptor (hFcγR) model enabling the assessment of Fc receptor pathways targeted therapies.

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Applications of the hFcγR mouse model

Broad range of applications in the fields of immuno-oncology, infectious diseases, inflammation and autoimmunity:

  • Assess the Fc-mediated effector function of biologics:
    • Evaluation of B-cell depletion following treatment with anti-CD20 antibodies
    • Testing the protective role of antibodies in the context of infection, such as influenza
    • Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
  • Rank Fc-engineered antibodies with enhanced or reduced binding to FcγR
  • Gain insight into the mechanism of action (MOA) of biologics

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Features

  • Fully immunocompetent model
  • hFcγR mice have a human-like expression pattern
  • No expression of murine FcγR
  • Functional receptors enabling assessment of Fc-mediated effector functions

Clients

argenx

Scientific articleScientific articlePosterPoster

VIB

Scientific articleScientific articlePosterPoster

Innate Pharma

Scientific articleScientific articlePosterPoster

Related resources and publications

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

pain research

nutrition

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

schizophrenia

Senescence-associated secretory phenotype (SASP)

seizure

sarcoidosis

rhesus-deficiency syndrome

retinopathy

retinitis pigmentosa (RP)

retinal dystrophy disorder

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Novel FcγR humanized mouse models enabling efficacy and PK/PD of therapeutic antibodies

FcγR mouse models for efficacy and PK/PD

Apr 2024
Cell-depleting agents assessment in preclinical models

BRGSF-HIS & hFcγR to assess cell depletion

Nov 2023
(VIB) A Cross-Species Map and Humanized Mouse Model of Fcγ Receptors and FcRn

Humanized Mouse Model of Fcγ Receptors

Sep 2023
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