Applications of the hFcγR mouse model

Broad range of applications in the fields of immuno-oncology, infectious diseases, inflammation and autoimmunity:

  • Assess the Fc-mediated effector function of biologics:
    • Evaluation of B-cell depletion following treatment with anti-CD20 antibodies
    • Testing the protective role of antibodies in the context of infection, such as influenza
    • Ex vivo assessment of antibody-dependent cellular cytotoxicity (ADCC) induced by different monoclonal antibodies
  • Rank Fc-engineered antibodies with enhanced or reduced binding to FcγR
  • Gain insight into the mechanism of action (MOA) of biologics

Features

  • Fully immunocompetent model
  • hFcγR mice have a human-like expression pattern
  • No expression of murine FcγR
  • Functional receptors enabling assessment of Fc-mediated effector functions

Related resources and publications

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