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Pan hCD3
Humanized mice (target-specific)

Preclinical Pan hCD3 mouse model

Pan hCD3 immunocompetent mice enable the efficacy assessment of T-cell engagers, to study cancer cell recognition, immunosuppressant therapies, etc.

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Applications of the Pan hCD3 mouse model

Useful applications for researchers working in different biomedical fields, such as immuno-oncology and autoimmunity:

  • Assess the efficacy of T-cell engagers (TCE)
    • Perform tumor inhibition assays
    • Test TCE for inhibition of autoimmune diseases‍
  • Evaluate the safety of therapeutics, such as inducing cytokine release syndrome (CRS) via treatment with anti-CD3 antibodies

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Features

  • Physiological expression of human CD3
  • Lack of expression of the murine target gene
  • Fully functional, and with unchanged homeostasis, mouse immune system
  • Functional CD3/TCR interaction
  • Functional T/B-cell cooperation

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Clients

Clients

AstraZeneca

Scientific articleScientific articlePosterPoster

Related resources and publications

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

pain research

nutrition

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

schizophrenia

Senescence-associated secretory phenotype (SASP)

seizure

sarcoidosis

rhesus-deficiency syndrome

retinopathy

retinitis pigmentosa (RP)

retinal dystrophy disorder

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PosterS
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Scientific Articles
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(AstraZeneca) AZD5863: a specific, potent, affinity-optimized Claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing

CD3 binding T-cell engagement

Nov 2023
CD3 humanized mouse models as validated tools to assess immune-related adverse events of T-cell engagers

CD3 and BRGSF-HIS to assess IrAEs

Nov 2022
Translatable preclinical mouse models for assessment of T-cell engager-induced CRS

BRGSF-HIS & CD3ε in CRS

Apr 2022
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Sci Rep

Jan 2022
Highlighted article
read the comment
HPN328, a new T cell–activating construct for treating solid tumors

CD3ε - T-cell engager assessment

7 min read
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Jul 2024
Assessing T-cell engagers in vivo: How BRGSF-HIS mice can help

Assess T-cell engager in BRGSF-HIS

6 min read
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Jun 2022
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

T-cell engager CD3

3 min read
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Mar 2022
Relevant preclinical models to test T-cell engagers: The case of CD28

T-cell engager

5 min read
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Mar 2022
A novel preclinical and translational humanized CD3ε model to study the efficacy of T-cell engagers

T-cell engager

8 min read
-
Feb 2021
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