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Applications of the genO‑panhCD3 mouse model
Useful applications for researchers working in different biomedical fields, such as immuno-oncology and autoimmunity:
- Assess the efficacy of T-cell engagers (TCE)
- Perform tumor inhibition assays
- Test TCE for inhibition of autoimmune diseases
- Evaluate the safety of therapeutics, such as inducing cytokine release syndrome (CRS) via treatment with anti-CD3 antibodies
Features
- Physiological expression of human CD3
- Lack of expression of the murine target gene
- Fully functional, and with unchanged homeostasis, mouse immune system
- Functional CD3/TCR interaction
- Functional T/B-cell cooperation
Clients
