Target

Gene symbol :  
Vsig4
NCBI gene ID :  
278180
Gene full name :  
V-set and immunoglobulin domain containing 4
Synonym :  
Z39Ig, CRIg

Protein function

Protein name :  
VSIG4
Complement receptor on macrophages; negatively regulates T-cell responses.

Expected phenotype

Enhanced T-cell activation, altered immune clearance

Human disease relevance

Target in autoimmunity, sepsis, and cancer immunity

Model applications

Complement regulation, macrophage function

Keywords:

CRIg, Complement, Immune checkpoint

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • WoldWide delivery by professional breeders

Vsig4

conditional Knockout Mouse

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