A VISTA on naive T cell fate
![science.mag](https://cdn.prod.website-files.com/655dd3c88278aa64954052d4/659cff24a26d8585f23d57ca_science-head.jpeg)
Humanized Immune Checkpoint VISTA mouse model contributes to research published in Science
ElTanbouly MA, Zhao Y, et al. Science. 2020
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
A humanized VISTA mouse developed by genOway has proved to be an excellent tool to unveil a new role for this immune checkpoint inhibitor, already known to play a key role in suppressing T cell activation.
In this study, freshly published in Science, a team of researchers at the Geisel School of Medicine at Dartmouth and ImmuNext performed in vivo analyses, demonstrating that VISTA is critical in maintaining T cell self-tolerance. This was elegantly shown by targeting VISTA with agonist and antagonist antibodies, whose specificity was assessed in the humanized VISTA mouse model as well as in other human and murine samples.
![](https://cdn.prod.website-files.com/655dd3c88278aa64954052d4/659cff24539e0bc52a4387ca_science-hvista.jpeg)
Ultimate predictive models
Physiological relevance
Comprehensive and reliable validation data
Over 600 scientific articles based on our modelsScientific excellence
In-depth expertise in preclinical science, physiology, and model development
Unique R&D platform located in FranceCustomer-centric
Tailor-made approach to your needs
Strong emphasis on customer satisfactionCollaborative partner
Long-standing partnerships with 17 of the top 20 pharma companies
Co-development of innovative models for next-generation drugs
Guaranteed FTO/freedom to operate