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Applications of the genO‑hVISTA mouse model
Valuable applications for researchers in various biomedical fields, including immuno-oncology and immuno-inflammation:
- Assess the efficacy of VISTA-targeting compounds:
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Identify new possible therapies
- Evaluate the safety and toxicity of compounds
- Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits
- Analyze the PK profile and the biodistribution of hVISTA-targeting compounds
Features
- Physiological regulation and expression pattern of the human VISTA
- Fully functional mouse immune system
- Lack of expression of the murine target gene
- The hVISTA model is designed to enable the easy generation of a VISTA conditional Knockout mouse for tissue-specific assessment of compounds’ specificity and toxicity
Clients
