Design of the hVISTA mouse
The humanized VISTA mouse model (hVISTA) is developed by Knockin at the mouse VISTA locus, and expresses a chimeric VISTA with a human extracellular, human transmembrane and murine intracellular domain.
The design also gives access to VISTA conditional Knockout mice for a tissue-specific assessment of compounds’ specificity and toxicity.
hVISTA features
- The VISTA extracellular domain is entirely humanized
- Physiological regulation and expression pattern of the human VISTA
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity