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Applications of the hCD3ε mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology and autoimmunity:
- Assess the efficacy of T-cell engagers targeting the CD3 SP34 epitope, such as by performing tumor growth inhibition assays
- Perform long-term studies as immunological memory is observed in the CD3ε model following treatment
- Evaluate the safety assessment studies for analyzing the potential of inducing cytokine release syndrome (CRS) upon treatment with anti-CD3 antibodies
Features
- Conserved interaction with CD3γ, CD3δ and CD3ζ subunits
- Physiological expression of human CD3
- Functional T/B-cell cooperation
- Fully functional mouse immune system
Clients
