Applications of the hCD3ε/hCD28 mouse model

Useful applications for researchers working on different biomedical fields, such as immuno-oncology and autoimmunity:

  • Assess the efficacy of CD28 and/or CD3ε (SP-34)-targeting therapeutics such as:
    • Immune checkpoint inhibitors
    • T-cell engagers targeting the CD3 SP34 epitope
  • Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

 Features

  • Physiological regulation and expression pattern of CD3ε and human CD28
  • Conserved interaction with CD3γ, CD3δ and CD3ζ subunits
  • Fully functional mouse immune system
  • Lack of expression of the murine target genes

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