Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.

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Knockout models

Knockout models, a cornerstone in biomedical research, involve the targeted inactivation of specific genes to understand their function. By "knocking out" a gene, you can observe the resulting phenotype changes, shedding light on the gene's role in health and disease.

Platforms like the European Conditional Mouse Mutagenesis Program contribute significantly, providing a standardized approach to generating and studying Knockout mice. These models are instrumental in deciphering gene functions, offering crucial insights into molecular pathways and potential therapeutic targets.

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Reporter models

Reporter models are genetically modified with reporter genes, like fluorescent proteins, to enable real-time visualization of specific biological processes.

They serve as invaluable tools for researchers, providing dynamic insights into disease progression, treatment responses, and the effects of genetic modifications.

By observing the behavior of reporter genes in living animals, scientists gain a deeper understanding of complex biological mechanisms, making these models indispensable in advancing biomedical research.

Discover our

Knockout and reporter models

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Btk rat

Btk Knockout rat to study B-cell malignancies, aberrant B-cell responses, Btk inhibitors for treatments of hematologic cancers or autoimmune diseases.

BTK

Immunodeficient

KO-Rep-Mix

IL-4-IRES-eGFP

The reliable monitoring and sorting of IL-4-secreting cells allows you to efficiently delineate the immune response polarization toward the Th2 pathway.

IL-4

KO-Rep-Mix

GFP rat

The GFP rat is suitable for organ & tissue transplantations and used in many biomedical fields (development, toxicology, orthotopic transplantation).

GFP

KO-Rep-Mix

KO repository

>2000 conditional Knockout mouse models for target discovery and confirmation, in vivo compound specificity, MOA, and clinical studies

Eucomm

KO-Rep-Mix

HSA/hFcRn-Rag1-KO

This upgraded, immunocompromised Rag1^-/- version of our HSA/hFcRn mouse model allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

HSA

PK/PD

Fc receptor

KO-Rep-Mix

Discover our customized models

Related resources and publications

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

pain research

nutrition

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

schizophrenia

Senescence-associated secretory phenotype (SASP)

seizure

sarcoidosis

rhesus-deficiency syndrome

retinopathy

retinitis pigmentosa (RP)

retinal dystrophy disorder

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GalNT2-mediated O-glycosylation affects pancreas development and function in mice

Sci Rep

NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Biomaterials

Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

Geroscience

Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

Invest Ophthalmol Vis Sci

Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution

JCI Insight

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression

Mol Cancer Ther

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Nat Neurosci

Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells

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Fitusiran reduces bleeding in Factor X-deficient mice

Blood

Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia

Neurobiol Dis

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function

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Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes

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Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice

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Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

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Multilineage commitment of Sca-1+ cells in reshaping vein grafts

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Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning

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Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

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NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

iScience

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia

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Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

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The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma

Cancer Res

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

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Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

Glia

Detecting Central Auditory Processing Disorders in Awake Mice

Brain Science

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion

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A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Nat Metab

Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection

Sci Rep

An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

Acta Neuropathol

Apelin controls emotional behavior in age- and metabolic state-dependent manner

Psychoneuroendocrinology

Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis

Prog Neurobiol

Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice

Mol Psychiatry

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Breast Cancer Res

DLL3 regulates Notch signaling in small cell lung cancer

iScience

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Nat Commun

Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH

Biochim Biophys Acta Mol Basis Dis

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Cell Metab

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

PLoS One

R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System

Int J Mol Sci

ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways

Biol Trace Elem Res

Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain

Brain

JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

Cell Rep

Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity

iScience

A methionine-Mettl3-N 6-methyladenosine axis promotes polycystic kidney disease

Cell Metab

ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity

J Invest Dermatol

Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall

Cell Rep

Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract

Cardiovasc Res

Characterization of Poldip2 knockout mice: avoiding incorrect gene targeting

PLoS One

CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

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Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32

Cell Mol Immunol

Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair

J Biol Chem

Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease

Matrix Biol

Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T cell responses to acute and chronic viral infection

Eur J Immunol

Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration

JCI Insight

Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Proc Natl Acad Sci U S A

Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist

Proc Natl Acad Sci U S A

Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis

PLoS One

IL23R on myeloid cells is involved in murine pulmonary granuloma formation

Exp Lung Res

Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse

Biochem Biophys Rep

Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model

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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Cell

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The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice

Proc Natl Acad Sci U S A

Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model

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ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity

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AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice

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Cathepsin S Evokes PAR (2)-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models

Cancers (Basel)

Implication of folate deficiency in CYP2U1 loss of function

J Exp Med

Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope

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Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2

J Neurosci

Novel compounds with dual S1P receptor agonist and histamine H 3 receptor antagonist activities act protective in a mouse model of multiple sclerosis

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Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

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Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury

J Neurosci

Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

Nat Neurosci

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Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma

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Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells

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Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease

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Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1+/− Mice

Int J Mol Sci

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

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HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis

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Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration

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Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response

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Nolz1 expression is required in dopaminergic axon guidance and striatal innervation

Nat Commun

The Non-Receptor Tyrosine Kinase Pyk2 Modulates Acute Locomotor Effects of Cocaine in D1 Receptor-Expressing Neurons of the Nucleus Accumbens

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αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

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Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

Cell

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Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

J Am Heart Assoc

FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Cell Metab

MOSPD2 is a therapeutic target for the treatment of CNS inflammation

Clin Exp Immunol

A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis

Cell Rep

An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials

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Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels

Transl Psychiatry

Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic Thy1-Gfp Rat Model

JAMA Facial Plast Surg

Constitutive serotonin transporter reduction resembles maternal separation with regard to stress-related gene expression

ACS Chem Neurosci

Deubiquitinase USP10 regulates Notch signaling in the endothelium

Science

Helicase-like transcription factor (Hltf) gene-deletion promotes oxidative phosphorylation (OXPHOS) in colorectal tumors of AOM/DSS-treated mice

PLoS One

Identification of an ATP-sensitive potassium channel in mitochondria.

Nature

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Cell Metab

Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.

Nitric Oxide

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.

Cell Rep

6 good reasons to employ our repository Knockout mouse models in your in vivo studies

Eucomm conditional Knockouts

A Knockin C3-reporter mouse model represents a valuable tool to monitor C3 levels, a biomarker of inflamed versus uninflamed tissues

Customized mouse model

The importance of genetic design when choosing your preclinical model - A Case Study on GLP-1R

Physiological relevancy in preclinical models

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Other categories

Immunodeficient rodents

Explore our immunodeficient models, featuring cutting-edge strains like BRGSF mouse and SDRG rat.

Humanized mice (HIS/human immune system)

Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Humanized mice (target-specific)

Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.