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IL-4 is the canonical marker of Th2 cells and is known to induce differentiation of naive helper T cells to Th2 cells by polarizing the immune response toward a humoral effector response.
In contrary to other existing IL-4 reporter models generated by random insertion, this Knockin mouse line preserves the physiological expression of IL-4 and enables monitoring of Th2 activity.
Features
No deregulation of endogenous IL-4 expression:
- Endogenous IL-4 is expressed and functional: reporter gene inserted in the 3'UTR of the endogenous IL-4 locus
- Genetic manipulation inserted is controlled
- Reporter faithfully mirrors IL-4 expression
Suitable model for your Th2 polarization monitoring studies:
- IL-4 expressing cells could be directly detected by monitoring eGFP expression (Fig. 1)
- Uncompromised immune system: intact production of IL-4 in response to infection or challenge (Fig. 2)
- Optimum monitoring of Th2 cell trafficking and cell sorting
Clients
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