Humanized PD-1/PD-L1 mouse and cell line
Front Immunol
PLoS One
Immunology
A constitutive Knockout cell line refers to a conventional KO; a model in which the target gene is permanently inactivated, and no protein is produced.
A constitutive Knockout cell line, also referred to as conventional Knockout (KO), defines a model in which the target gene is permanently inactivated.
No protein is produced.
For academic research:
For bio-pharmaceutical research & development:
→ Risks can be strongly minimized by applying in-depth bio-informatic, genetic, and bibliographic analyses
→ An alternative model is a functional Knockout by introducing a point mutation to produce an inactive protein
Humanized PD-1/PD-L1 mouse and cell line
Front Immunol
PLoS One
Immunology
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