.png)
.png)
Applications of the hCD47/hSIRPα mouse model
Useful applications for researchers working in different biomedical fields, such as immuno-oncology, inflammation and autoimmunity:
- Assess the efficacy of CD47- and/or SIRPα-targeting therapeutics
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Evaluate the safety and toxicity of compounds
- Analyze the biodistribution of CD47- and/or SIRPα-targeting compounds
- Investigate the mode of action (MoA) of CD47- and/or SIRPα-targeting compounds and understand their therapeutic potential
Features
- Expression of different human CD47 and human SIRPα isoforms
- Physiological regulation and expression patterns of the human CD47 and human SIRPα
- Preservation of the target-ligand interaction
- Fully functional mouse immune system
- Lack of expression of the murine target genes, thus avoiding cross-reactivity
Clients
.webp)
.webp)
.webp)
