Design of the hOX40 mouse
The humanized OX40 mouse model (hOX40) is developed by Knockin at the mouse OX40 locus, and expresses a fully humanized OX40 with a human extracellular, transmembrane and intracellular domain.
hOX40 features
- Physiological regulation and expression pattern of the human OX40
- Preservation of the target-ligand interaction
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Anti-tumor efficacy and tumor-specific immunological memory were proven in MC38 and MB49 tumor models.