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Applications of the genO‑HSA/hFcRn mouse model
Broad range of applications in the fields of immuno-oncology, infectious diseases and autoimmunity:
- Assess pharmacokinetics and pharmacodynamics (PK/PD) features, including biodistribution and binding affinity
- Screen compounds based on extended half-life
- Assess the efficacy of optimized therapeutics such as Fc-engineered antibodies, constructs fused to HSA, HSA- and/or FcRn-binding proteins or small molecules
Features
- Physiological expression and distribution of HSA and human FcRn
- Lack of expression of the murine target genes
- Higher physiological affinity of human serum albumin to human FcRn
- Unaltered blood chemistry compared to a wild-type mouse
Clients
