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hIgE/hFcεR1
Humanized mice (target-specific)

Humanized IgE/FcεR1 mouse model

Use the hIgE/hFcεR1 mouse model to successfully screen for innovative therapeutics for allergy, asthma and other IgE-mediated diseases.

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Applications of the hIgE/hFcεR1 mouse model

Useful applications for researchers working in immuno-inflammation and allergic diseases: 

  • Assess the efficacy of IgE-targeting therapeutics
    • Test therapeutics that block anaphylaxis (passive or active) and help controling asthma
  • Develop models of Passive Cutaneous Anaphylaxis (PCA), OVA hypersensitivity and Passive systemic anaphylaxis (PSA)
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

 

 Features

  • Human-like cellular distribution (i.e., mast cells, basophils, monocytes/DCs, Langerhans cells, and eosinophils) of the FcεR1 receptor
  • Physiological regulation and expression of the chimeric IgE/FcεR1 complex
  • Preservation of ligand-receptor interaction
  • Preservation of the Ig class switching mechanism
  • Human IgE is present, but at low levels
  • Fully functional mouse immune system
  • Lack of expression of the murine target genes

Clients

Carterra

Scientific articleScientific articlePosterPoster

IgGenix

Scientific articleScientific articlePosterPoster

Ambiotis

Scientific articleScientific articlePosterPoster

Related resources and publications

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intrauterine growth deficiency

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muscle-eye-brain disease (MEB)

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primary immunodeficiency (PID)

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immune response

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central nervous system (CNS)

taste

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autoimmunity

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sugar homeostasis

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pulmonary research

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pain research

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locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

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tauopathy

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small cell lung cancer

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seizure

sarcoidosis

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retinopathy

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Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

Sep 2023
No results
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Validation data

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