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hIgE/hFcεR1
Humanized mice (target-specific)

Humanized IgE/FcεR1 mouse model

Use the hIgE/hFcεR1 mouse model to successfully screen for innovative therapeutics for allergy, asthma and other IgE-mediated diseases.

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Applications of the hIgE/hFcεR1 mouse model

Useful applications for researchers working in immuno-inflammation and allergic diseases: 

  • Assess the efficacy of IgE-targeting therapeutics
    • Test therapeutics that block anaphylaxis (passive or active) and help controling asthma
  • Develop models of Passive Cutaneous Anaphylaxis (PCA), OVA hypersensitivity and Passive systemic anaphylaxis (PSA)
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

 

 Features

  • Human-like cellular distribution (i.e., mast cells, basophils, monocytes/DCs, Langerhans cells, and eosinophils) of the FcεR1 receptor
  • Physiological regulation and expression of the chimeric IgE/FcεR1 complex
  • Preservation of ligand-receptor interaction
  • Preservation of the Ig class switching mechanism
  • Human IgE is present, but at low levels
  • Fully functional mouse immune system
  • Lack of expression of the murine target genes

Clients

Carterra

Scientific articleScientific articlePosterPoster

IgGenix

Scientific articleScientific articlePosterPoster

Ambiotis

Scientific articleScientific articlePosterPoster

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von Willebrand disease (VWD)

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No results
Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

Sep 2023
No results
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Validation data

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