(VIB) A Cross-Species Map and Humanized Mouse Model of Fcγ Receptors and FcRn

Humanized Mouse Model of Fcγ Receptors

September 15, 2023

Introduction

Between-species differences in Fcγ receptors limit the use of mice as a preclinical model to study antibody function. We map human and murine Fcγ receptors expression, and introduce a novel mouse line which expresses human FcγRI, FcγRIIA/B, FcγRIIIA/B and FcRn, replacing their murine counterparts. This resource and unique model will advance the preclinical assessment of antibody-based therapeutics.

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hFcγR

Preclinical humanized Fc-gamma receptor (hFcγR) model enabling the assessment of Fc receptor pathways targeted therapies.

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