(VIB) A Cross-Species Map and Humanized Mouse Model of Fcγ Receptors and FcRn

Humanized Mouse Model of Fcγ Receptors

September 15, 2023

Introduction

Between-species differences in Fcγ receptors limit the use of mice as a preclinical model to study antibody function. We map human and murine Fcγ receptors expression, and introduce a novel mouse line which expresses human FcγRI, FcγRIIA/B, FcγRIIIA/B and FcRn, replacing their murine counterparts. This resource and unique model will advance the preclinical assessment of antibody-based therapeutics.

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hFcγR

Preclinical humanized Fc-gamma receptor (hFcγR) model enabling the assessment of Fc receptor pathways targeted therapies.

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Scientific excellence
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Robust validation data on catalog models
Comprehensive dataset package
Generated with biopharma partners and in-house
Customer care
Scientific follow-up and advice alongthe project
Collaborative approach for problem solving and development of innovative models
Easy and fast access to models
Breeding facilities in US and Europe
Certified health status from professional breeders

Humanized targets