Home
Off-the-shelf
Humanized mice (target-specific)
hIgE/hFcεR1
Humanized mice (target-specific)

Humanized IgE/FcεR1 mouse model

Use the hIgE/hFcεR1 mouse model to successfully screen for innovative therapeutics for allergy, asthma and other IgE-mediated diseases.

Contact Us

Applications of the hIgE/hFcεR1 mouse model

Useful applications for researchers working in immuno-inflammation and allergic diseases: 

  • Assess the efficacy of IgE-targeting therapeutics
    • Test therapeutics that block anaphylaxis (passive or active) and help controling asthma
  • Develop models of Passive Cutaneous Anaphylaxis (PCA), OVA hypersensitivity and Passive systemic anaphylaxis (PSA)
  • Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential

 

 Features

  • Human-like cellular distribution (i.e., mast cells, basophils, monocytes/DCs, Langerhans cells, and eosinophils) of the FcεR1 receptor
  • Physiological regulation and expression of the chimeric IgE/FcεR1 complex
  • Preservation of ligand-receptor interaction
  • Preservation of the Ig class switching mechanism
  • Human IgE is present, but at low levels
  • Fully functional mouse immune system
  • Lack of expression of the murine target genes

Clients

Carterra

Scientific articleScientific articlePosterPoster

IgGenix

Scientific articleScientific articlePosterPoster

Related resources and publications

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

cGAS

cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

Oncology

Pharmacology

Neuroscience

Metabolism

Inflammation

Immunology

Respiration

Cardiovascular

Ophthalmology

Nephrology

Musculoskeletal

Hematology

Epigenetics

Development

Endocrinology

Dermatology

Humanization

Rosa26

TET system

Hprt

CreERt2

FLEx

innate immunity

Transgenesis

infection

vision

immune response

dementia

central nervous system (CNS)

taste

transplantation

autoimmunity

thermoregulation

sugar homeostasis

stress

skelet

pulmonary research

pain research

nutrition

muscle research

locomotion

memory

hearing

fat homeostatsis

tissue research

epigentic modification

drugs

cancer research

cell research

behavior

aging

stem cell research

reproductive research

lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

blood research

von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

SHORT syndrome

sepsis

schizophrenia

Senescence-associated secretory phenotype (SASP)

seizure

sarcoidosis

rhesus-deficiency syndrome

retinopathy

retinitis pigmentosa (RP)

retinal dystrophy disorder

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
PosterS
(
0
)
Scientific Articles
(
0
)
CommentarIes
(
0
)
Case studies
(
0
)
No results
Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

Sep 2023
No results
No results
No results

Validation data

Discover related products to

hIgE/hFcεR1

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
HSA
PK/PD
Fc receptor

HSA/hFcRn

Double humanized HSA-hFcRn mouse model as a cutting-edge platform for preclinical development of HSA and FcRn-oriented therapeutics.

HSA
PK/PD
Fc receptor
KO-Rep-Mix

HSA/hFcRn-Rag1-KO

This upgraded, immunocompromised Rag1-/- version of our HSA/hFcRn mouse model allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

CD4
Inflammation
T-cell receptor

hCD4

The human CD4 mouse model allows in vivo efficacy and safety assessment of anti-human CD4 compounds.

‍

FcgR
Fc receptor

hFcγR

Preclinical humanized Fc-gamma receptor (hFcγR) model enabling the assessment of Fc receptor pathways targeted therapies.

‍

Inflammation
TNF
Cytokine

hTNF-α

The hTNF-α model provides new opportunities for assessment of anti-TNF therapies.

Humanized IgE/FcεR1 mouse model

Get in touch about

Let us know how we can help

In order to provide you the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please tick the checkbox below.

From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please tick below.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.