Related resources and publications
Targeting the human CD47/SIRPα axis
Humanized ICP mouse and cell lines
Front Immunol
PLoS One
Immunology
The CT26.WT cell line was derived and subcloned from Balb/c murine colon carcinoma and forms tumors at high frequency when inoculated subcutaneously. We generated CT26-Pd-l1 Knockout clonal cell lines invalidated for murine Pd-l1 (Cd274).
The CT26-Pd-l1 Knockout clones can be used for target validation and mechanistic studies.
Humanized CT26-hPD-L1 cell line:
Use our humanized CT26-hPD-L1 cell line for in vivo tumor growth assays in syngeneic models.
Expression analysis by FACS. mPd-l1 expression in CT26‑Pd‑l1 Knockout (KO) clone and parental cell line.
Wild-type Balb/c mice were injected (s.c.) with 1x105 CT26.WT (A) or CT26-Pd-l1 KO (B) cells. Tumor growth was measured every 2 to 3 days. Tumor size (mm3) = (width2 x length)/2. 8 mice (mixed gender) were injected per group, with 8 mice developing tumors for CT26.WT and CT26-Pd-l1 KO.
Targeting the human CD47/SIRPα axis
Humanized ICP mouse and cell lines
Front Immunol
PLoS One
Immunology
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