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Applications of the hCD137 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology and autoimmunity:
- Assess the efficacy of CD137-targeting therapeutics, such as:
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Analyse their immunomodulation effect
- Investigate the mode of action (MoA) of CD137-targeting compounds and understand their therapeutic potential
Features
- Expression of different hCD137 isoforms
- Physiological regulation and expression pattern of the human CD137
- Fully functional mouse immune system
- Lack of expression of the murine target gene
Clients
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