Applications of the genO‑hPD‑1 mouse model

Useful applications for researchers working on different biomedical fields, such as  immuno-oncology, immuno-inflammation and autoimmunity:

  • Assess the efficacy of PD-1-targeting compounds
    • Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
    • Evaluate PD-1 agonists for the treatment of autoimmune and inflammatory conditions
  • Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits

Features

  • Physiological regulation and expression of a humanized PD-1
  • Lack of expression of the murine target gene
  • Fully functional mouse immune system
  • Available on different genetic backgrounds C57BL/6 & BALB/c

Related resources and publications

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