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Applications of the hGITR mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, inflammation and autoimmunity:
- Assess the efficacy of GITR-targeting therapeutics
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Evaluate GITR antagonists for the treatment of autoimmune and inflammatory conditions
- Investigate the mode of action (MoA) of GITR-targeting compounds and understand their therapeutic potential
- The GITR model supports long-term studies as immunological memory is observed following treatment
Features
- Expression of different GITR isoforms
- Physiological regulation and expression pattern of the human GITR
- Preservation of the target-ligand interaction
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
Clients
