Design of the hGITR/hGITRL mouse

The double-humanized GITR and GITRL mouse model (hGITR/hGITRL) was generated by intercrossing hGITR and hGITRL mice.

hGITR was developed by inserting, within the mouse GITR locus, a chimeric GITR with the human extracellular and the murine intracellular domain.

hGITRL was generated by inserting, within the mouse GITRL locus, a chimeric GITRL with the human extracellular and the murine intracellular domain.

Both hGITR and hGITRL expressions are regulated by endogenous mouse promoters.

hGITR/hGITRL features

  • GITR and GITRL extracellular domains are entirely humanized
  • hGITR and hGITRL expression driven by the respective endogenous mouse promoter
  • Preservation of the target-ligand interaction
  • Fully functional mouse immune system
  • Lack of expression of the murine target gene, thus avoiding cross-reactivity

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