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Applications of the hCTLA-4 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, inflammation and autoimmunity:
- Assess the efficacy of CTLA-4-targeting therapeutics
- Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
- Investigate the mode of action (MoA) of CTLA-4-targeting compounds and understand their therapeutic potential
- Evaluate the safety and toxicity of compounds
- The CTLA-4 model supports long-term studies as immunological memory is observed following treatment
Features
- Expression of different hCTLA-4 isoforms
- Physiological regulation and expression pattern of the human CTLA-4
- Preservation of the target-ligand interaction
- Fully functional mouse immune system
- Lack of expression of the murine target gene, thus avoiding cross-reactivity
- The hCTLA-4 model is designed to enable the easy generation of a CTLA-4 conditional Knockout mouse for tissue-specific assessment of compounds’ specificity and toxicity
Clients
